| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Student Poster Contest + Rapid Fire
|
| Presentation Title |
C-23: Polyurethane Biomaterials Tethered with Small Molecule via Polyethylene Glycol (PEG) Enhance Anti-Biofilm Properties |
| Author(s) |
Jiale Liu, Chen Chen, Harry Allcock, Christopher Siedlecki, Li-Chong Xu |
| On-Site Speaker (Planned) |
Jiale Liu |
| Abstract Scope |
Biofilm formation on implantable medical devices leads to serious infections. Small molecule interfering with bacterial intracellular nucleotide second messenger signaling is a promising approach to control biofilm formation. This study evaluates the effectiveness of small molecule derivatives of 4-arylazo-3,5-diamino-1H-pyrazole tethered on polyurethane surfaces in inhibition of biofilms using either long linker polyethylene glycol (PEG) or short liner hexamethylene diisocyanate (HMDI). The surfaces were characterized by XPS, AFM and wettability, and assessed with three biofilm strains, Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa. Agar plating counting showed both modified surfaces reduced biofilm growth but there was no notable difference between PEG-grafted and HMDI-grafted modified surfaces in terms of 24-hour biofilm growth. However, the PEG-grafted surfaces showed significantly enhanced biofilm inhibition after 72 hours compared to HMDI-grafted surfaces. These findings suggest that incorporating PEG as a linker will improve small molecule activity and enhance the long-term anti-biofilm properties of polyurethane biomaterials. |