About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics at the Extremes: Bridging Length-Scales From Nanoscale to Bulk
|
| Presentation Title |
Mechanics-to-milling: An indentation–impact framework for predictive bulk comminution |
| Author(s) |
Soumyadeep Sen, Tianyi Xiang, Jamshid Ochilov, Tianxiang Gao, Zijian Wang, Suraj Ravindran, Calvin Sun, Nathan Mara |
| On-Site Speaker (Planned) |
Soumyadeep Sen |
| Abstract Scope |
Predicting comminution behavior of pharmaceutical molecular crystals has been heavily reliant on lab scale milling tests and statistical models for decades. These long-standing industry practices demand significant material, time and energy consumption to predict breakage behavior of the feed material. This study implements nanoindentation (for quasi-static regime) and impact tests (for dynamic regime) to probe single crystals at nanoscale and predict comminution behavior at bulk scale. Nanoindentation based metrics like modulus (E), hardness (H), fracture toughness (KIC) were used to derive dimensionless ratios (H/E, H/KIC, plastic-fracture work ratios), which combined with another set of dimensionless descriptors obtained from laser induced particle impact testing (LIPIT) including coefficient of restitution and energy-partition indices lead to a proposed millability ranking index. Corroborating this index to percent d50 reductions from milling tests helped in deriving a reliable milling prediction model based on the high throughput nanomechanical characterization techniques spread over varying strain rates. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Mechanical Properties, |