About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Biomimetic Scaffolds for Anterior Cruciate Ligament (ACL) Repair |
| Author(s) |
Kalpana S. Katti, Pooyan Vahidi Pashaki, Priyanka Kumari, Preetham Ravi, Benjamin Noonan, Dinesh R. Katti, Sharad Jaswandkar |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
The anterior-cruciate-ligament (ACL) and the posterior-cruciate-ligament attach the femur and to the tibia in the knee joint. The ACL can be torn or injured during sporting activities, work injuries, or vehicular accidents. Current technologies utilize collagen-based scaffolds, needing arthrotomy for insertion and show deficient behavior in younger patients. We report a novel polymer-caprolactone (PCL) PCL-collagen-nanoclay-scaffold, that exhibits improved stiffness, biodegradation, and absorption. Aminoacid modified nanoclays enabe biomineralization of hydroxyapatite (HAP) in the clay galleries. The HAP-nanoclays provide both mechanical advantages as well as favorable biologics. The scaffold structural design enables a biological "internal brace" with Iliotibial band strip that has both biological and biomechanical advantages. The scaffold structure is thus patient-specific. Further, absorbable sutures are incorporated to strengthen the scaffold for surgical insertion. Studies using HUVEC and hMSC co-cultures indicate vasculature formation. The feasibility of the new scaffold is confirmed through successful ACL IT Band surgery in a cadaver model. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Composites, Characterization |