About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Synthesis of Poly(lactide) and Poly(lactones) Using Eutectic and Non-Eutectic Systems for Biodegradable Scaffold Applications |
| Author(s) |
Maria Priscila Quinonez Angulo, Karla Alejandra Barrera-Rivera, Saul Carrasco-Saavedra, Antonio Martínez‐Richa, José Román Torres-Lubian, Joaquin Barroso-Flores, Davita L. Watkins , Josué D. Mota-Morales |
| On-Site Speaker (Planned) |
Maria Priscila Quinonez Angulo |
| Abstract Scope |
Sustainable methods for producing biodegradable polymers are critical for biomedical and environmental advancements. We present a green approach to synthesizing poly(lactide) and poly(lactones) via organocatalyzed ring-opening polymerization (ROP), using lactates as renewable initiators. Polymerizations were performed in eutectic and non-eutectic mixtures of L-lactide and ε-caprolactone, allowing control over polymer structure and properties. Incorporating deep eutectic solvent monomers (DESms), derived from L-lactide and various lactones, expanded the scope of solvent-free, low-temperature ROP. This method eliminates conventional solvents while supporting polymerization under mild, environmentally friendly conditions.
The resulting polyesters were processed into three-dimensional (3D) macroporous scaffolds using a fused salt-templated technique. These scaffolds showed tunable degradation and cytocompatibility, supporting their application in bone tissue engineering. Overall, this strategy offers a sustainable, efficient platform for designing biodegradable scaffolds and contributes to greener polymer science. |