About this Abstract |
| Meeting |
MS&T26: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
3-D printed β-TCP–Bioglass Scaffolds for Improved Bone Regeneration with curcumin
|
| Author(s) |
Priya Kushram, Susmita Bose |
| On-Site Speaker (Planned) |
Priya Kushram |
| Abstract Scope |
The objective of this study was to develop a multifunctional 3D-printed β-tricalcium phosphate (β-TCP) scaffold incorporating bioglass (BG) and curcumin to improve bone regeneration and localized therapeutic delivery. We hypothesized that BG incorporation would enhance scaffold bioactivity and curcumin release, while sustained curcumin delivery would improve osteoblast activity and suppress osteoclast-mediated resorption. TCP-BG-curcumin scaffolds showed enhanced apatite formation and higher cumulative curcumin release compared to TCP-curcumin scaffolds under both acidic and physiological conditions. Osteoblast studies demonstrated significantly higher cell viability and alkaline phosphatase activity in TCP-BG-curcumin scaffolds, indicating enhanced osteogenic differentiation. Osteoclast studies showed reduced osteoclast activity and resorption pits in curcumin-loaded scaffolds, confirming suppression of osteoclastic activity. In vivo evaluation using a rat distal femur defect model showed increased new bone formation in TCP-BG-curcumin scaffolds (~22%) compared to TCP (~11%). These findings demonstrate that combining BG-mediated bioactivity with sustained curcumin release enhances osteogenesis and improves bone regeneration. |