About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Patient-Specific Hybrid K-wire and Medullary Conformal Stabilization for Osteosarcoma-affected Long Bones |
| Author(s) |
Behzad Amirzade, XingZhi Li, Laura E. Selmic, Ali Nassiri |
| On-Site Speaker (Planned) |
Behzad Amirzade |
| Abstract Scope |
Osteosarcoma progression and radiation therapy can substantially weaken long bones, increasing the risk of pathological fracture. This study evaluates a hybrid fixation strategy combining a conformal intramedullary stabilization implant with supplemental Kirschner wires (K-wires). Patient-specific finite element models were used to investigate how K-wire counts, size, orientation, and insertion angle affect construct behavior under multiple loading conditions. Mechanical performance was evaluated using residual load capacity, implant–bone micromotion, and stress concentrations within the fixation system. Preliminary findings suggest that supplemental K-wires may enhance mechanical support in patients previously treated with conformal intramedullary stabilization, particularly when the implant alone provides limited reinforcement. Finite element outputs were used to train an explainable machine-learning surrogate that predicts the mechanical benefit of supplemental fixation and supports selection of an appropriate K-wire configuration. This framework enables rapid, patient-specific assessment of hybrid stabilization in osteosarcoma-affected bones, with potential applications in both veterinary and human oncology. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Modeling and Simulation, Computational Materials Science & Engineering |