About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
Biomechanical Tuning of Composites for Tissue Engineering |
| Author(s) |
Dinesh Katti, Hanmant Gaikwad, Nanang Qosim, Priyanka Kumari, Pooyan Vahidi Pashaki, Mohan Edirisinghe, Kalpana Katti |
| On-Site Speaker (Planned) |
Dinesh Katti |
| Abstract Scope |
The tuning of mechanical properties of materials and, at the same time, controlling the biological responses of cells on the materials is critical for the design of biomaterials, especially for tissue engineering. Using a simulation-based materials design approach, we have synthesized polymer clay nanocomposite-based materials with predictable mechanical properties. We have extended this approach to computationally predict the biomineralization by human Mesenchymal Cells on the biomaterials. Using these approaches, we have successfully designed biomaterials with tunable mechanical properties and biological responses. We have achieved this by identifying optimal unnatural amino acids for nanoclay modification and choosing appropriate nanoclay loading to synthesize biomaterials for tissue engineering applications, for targeted mechanical properties, and the extent of tissue regeneration on the materials and scaffolds. Biomechanically functionally graded fibers for tissue engineering are also made with these biomaterials. |