| Abstract Scope |
Brain lesions remain a leading cause of mortality, demanding improved diagnostic technologies to reduce fatality rates effectively. Accurate measurement of intracranial pressure (ICP) is critical for diagnosing brain lesions. Currently, clinical practice relies on invasive wired ICP sensors implanted in the brain parenchyma. However, these wired devices present significant limitations, including an infection risk and constraints on long-term, real-time monitoring, which restrict their widespread clinical application. In our study, we introduce the first wireless biodegradable ICP sensor that combines high measurement accuracy with portability, significantly enhancing clinical usability. Our ICP sensor features a noise-cancelling structure to effectively eliminate noise in the highly variable intracranial environment, enabling precise high-resolution measurements of ICP waves. Importantly, our device is constructed with biodegradable materials, significantly decreasing the risks associated with secondary surgeries for sensor removal and allowing safe measurement in the parenchymal site for extended periods exceeding four weeks. |