About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biomaterials for 3D Printing of Scaffolds & Porous Materials
|
| Presentation Title |
Development of Secretome-Bioink 3D Printed Scaffolds for Cartilage Regeneration in Diabetes |
| Author(s) |
Namitchandra Nallapaneni, Indranath Mitra |
| On-Site Speaker (Planned) |
Namitchandra Nallapaneni |
| Abstract Scope |
Although stem cell therapies are a solution to intervertebral disc degeneration (IVD), their efficacy in diabetic conditions is limited due to cellular migration and delocalization. GelMA-10%PEGDA hydrogels, previously shown to restore loss of function in IVD, provide an ideal biomaterial foundation for stem cell encapsulation. We fabricated GelMA-10%PEGDA hydrogels via visible light digital light processing using a stem cell-laden bioink. To functionally restore IVD under diabetic conditions, the scaffold was enriched with endothelial and macrophage secretomes–cellular metabolic secretions. Endothelial secretomes have been shown to support stem cell survival under diabetic stress, whereas macrophage secretomes have been shown to actively promote IVD restoration. The objective is to develop a novel bioactive bioink, comprising a dual-secretome formulation and stem cells, to overcome the cytotoxic and regenerative barriers of diabetic cartilage repair. We hypothesize that the resulting cell-laden scaffolds will both mitigate stem cell delocalization and synergistically enhance diabetic IVD restoration. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Additive Manufacturing |