About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Engineering Degeneration-Inspired Trabecular Microenvironments Through Voronoi Architectures and Biointerface Design for Osteogenic Rescue |
| Author(s) |
Jasmine Carpenter, Pratheesh Kanakarajan Vijaya Kumari, Vijaya Kumari, Derrick Dean, Vineeth Vijayan |
| On-Site Speaker (Planned) |
Vineeth Vijayan |
| Abstract Scope |
Three-dimensional architected biomaterials are widely investigated for bone regeneration; however, most studies evaluate osteogenesis in structurally favorable scaffold architectures that poorly represent compromised bone microenvironments. Here, we developed a degeneration-inspired Voronoi scaffold platform in which point spacing serves as a tunable architectural parameter to model progressive trabecular deterioration. Computational modeling, mechanical characterization, and comparison with clinically reported HR-pQCT datasets established healthy-like and degeneration-inspired architectural states. Human mesenchymal stem cells cultured in progressively deteriorated scaffolds exhibited reduced cytoskeletal organization and osteogenic mineralization, demonstrating that architecture alone regulates regenerative performance. Polydopamine surface modification enhanced cytoskeletal organization and partially restored osteogenic mineralization without altering scaffold geometry. A quantitative Mineralization Rescue Percentage (MRP) metric demonstrated up to 43% recovery of mineralization loss. This clinically contextualized platform establishes a framework for designing architected biomaterials that model compromised bone microenvironments and enable surface-mediated regenerative rescue. |
| Proceedings Inclusion? |
Planned: |