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Meeting 2026 TMS Annual Meeting & Exhibition
Symposium Late News Poster Session
Presentation Title A-20: Structure-Tuning of GelMA Hydrogels by Physical Gelation Induction as a Strategy for the Development of Drug Delivery Systems
Author(s) Cristina Padilla, Vanessa Campos, Eduardo Gonzalez, Javier Enrione
On-Site Speaker (Planned) Cristina Padilla
Abstract Scope Gelatin methacryloyl (GelMA) hydrogels are good candidates for the development drug delivery systems (DDS). However, the use of GelMA inherent physical gelation to control hydrogels structuring and molecule release has been poorly studied. This research aims to produce and characterize GelMA hydrogels by combining the contribution of physical gelation as well as gelatin source. Our source of gelatin was our own well characterized laboratory-extracted salmon gelatin (SG) mixed with porcine gelatin in different proportions to produce GelMAs with two degrees of substitution (DS). Results showed that when a higher proportion of SG was present in the samples, the gelation temperature and mechanical properties decreased. In addition, these properties also decreased when increasing the DS, while physical gelation induction increased both parameters. Preliminary studies showed that physical gelation also modulated the kinetics of molecule release in vitro, suggesting that this strategy could potentially produce different release profiles of bioactives.
Proceedings Inclusion? Undecided
Keywords Biomaterials, Characterization, Mechanical Properties

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