| Abstract Scope |
ZZr47Cu40Al8Ag5 was synthesized through copper mould suction casting and analyzed for its structural, mechanical, electrochemical, and biological properties. The amorphous structure of the BMG was verified using X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM). Nanoindentation tests determined the BMG's hardness and Young’s modulus to be 9.41±1.59 GPa and 99.5±5 GPa, respectively. The corrosion resistance of Zr47Cu40Al8Ag5 BMG was assessed under various simulated body fluid conditions, demonstrating excellent resistance, particularly in Hank's balanced saline solution (HBSS). Biocompatibility was assessed through MTT assays, surface marker analysis, gene expression studies, and osteogenic differentiation assays with dental pulp stem cells (DPSCs). The BMG exhibited low cytotoxicity, enhanced cell viability, and promoted osteogenic differentiation, indicating its potential for orthopaedic and dental implant applications. The combination of alloys offers strong mechanical properties, biocompatibility, and corrosion resistance, making Zr47Cu40Al8Ag5 BMG a promising candidate for biomedical implant materials. |