| Abstract Scope |
This talk explores two approaches for delivering drugs with poor water solubility, including piezoelectric inkjet printing of the drug and matrix-assisted pulsed laser evaporation of the drug. In one study, we describe the use of piezoelectric inkjet printing to deposit voriconazole, an antifungal agent with poor water solubility, on the surface of polyglycolic acid microneedles (doi:10.1116/1.4913378). Unlike the unmodified and vehicle-modified microneedles, the voriconazole-modified microneedles showed antifungal activity against Candida albicans. In another study, matrix assisted pulsed laser evaporation was used to deposit the antifungal agent amphotericin B on the surface of polyglycolic acid microneedles (doi:10.18063/IJB.2017.02.004). The zones of inhibition for a unmodified microneedle array, a matrix-assisted pulsed laser evaporation-coated microneedle array made using a 1040 mg amphotericin B/mL target, and a matrix-assisted pulsed laser evaporation-coated microneedle array made using a 2080 mg amphotericin B/mL target were 0 mm, 11 mm, and 18 mm, respectively. |