About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Copolymer Nanoparticles for Neuro regeneration/protection, Wound Healing, tissue regeneration and anti-inflammation |
| Author(s) |
Pradip Paik, Divya Pareek, Kirti Wasnik, Sukanya Patra, Vinoy Thomas |
| On-Site Speaker (Planned) |
Pradip Paik |
| Abstract Scope |
Amino acid-based block copolymer nanoparticles with cross-linkers have garnered growing interest in recent years. However, its’ intricate synthesis and purification difficulties, along with stability concerns linked to inter-micellar crosslinking, restrict their potential use in healthcare and therapeutic applications. In this line, the present work is aimed to design amphiphilic block copolymer nanoparticles, with and without using a cross-linker via mini-emulsion free radical polymerization. The self-assembled π-π stacking structural arrangement of copolymer at different temperatures has been confirmed through the molecular dynamics (MD) simulation, which corroborated the structural stability of copolymer nanoparticles at physiological temperature. The cell migration results polymeric nanoparticles are complementary to the CEMA assay and reveal their use in neuro-regeneration, Wound Healing, tissue regeneration and anti-inflammation. Further, the in vivo wound healing study demonstrated that within 13 days of post-treatment, the wound can be healed ~97%, whereas for the control, it is found to be only ~80%. Additionally, the RT-PCR results revealed that polymeric nanoparticles possess anti-inflammatory and tissue regeneration properties by down regulating TNF-α and IL-1β; and up regulating PECAM-1 and VEGF-A, respectively. In conclusion, novel nanoparticles are paramount with an extensive clinical potential for the regeneration of acute wounds and can be used for therapeutic applications and for the reduction of systemic inflammation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Nanotechnology |