| Author(s) |
Antonia Ressler, Tomislav Ivankovic, Jasna Hrenovic, Inga Urlic, Setareh Zakeri, Blanka Dadic, Virginia Alessandra Gobbo, Ivana Goic-Barisic, Jonathan Massera, Erkki Levänen |
| Abstract Scope |
Certain bacterial species are a persistent issue in hospital-acquired infections due to their fast and potent development of multi-drug resistance. To address this urgent challenge, this study aimed to evaluate the antibacterial activity of mono-doped hydroxyapatite (HAp), incorporating potentially antibacterial ions (Sr2+, Zn2+, Mg2+, SeO32-, Ag+, Ce3+, Cu2+, Ga3+ and Mn2+), against clinical isolates Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. All materials were non-cytotoxic to cells, except for Cu-doped HAp. HAp doped with Ag+ showed significant antibacterial activity against all tested bacteria. Ce-doped HAp showed no antibacterial effect, while Ga-, Se-, Zn-, Mg-, Se- and Mn-doping indicated potential antibacterial properties towards certain bacterial strains by inhibiting bacterial attachment and survival. The Gram-negative bacteria attached to the HAp surface in a lesser amount then the Gram-positive ones. The antibacterial activity of Ag-doped HAp toward A. baumannii was time-dependent and should be considered in potential applications. |