About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
In-Vitro Response and Raman Characterization of Helically Coiled Electrospun Fibers for Cardiac Patch |
| Author(s) |
Alexi Switz, Anamika Prasad, Darryl Dickerson |
| On-Site Speaker (Planned) |
Alexi Switz |
| Abstract Scope |
The electrospinning method is increasing in tissue engineering due to its ability to produce fibers in the nanometer to micrometer range. Such applications also demand greater control on fiber formation since fiber orientation dictates mechanical flexibility, strength, porosity, and cellular response. Here we present the characterization of helically coiled and aligned electrospun fibers. Helically coiled structures were chosen for fiber design since such structures are common in nature in both the plant and animal worlds but have found limited application in tissue engineering. Polycaprolactone, an FDA-approved material was used for fiber formation. The function and biocompatibility of fibrous scaffolds was tested including its response to cardiomyocytes and fibroblasts using a specially designed tissue setup. The outcome was compared with aligned fibrous mats to evaluate the effectiveness of helical coiling. Cardiomyocytes, fibroblasts and patches were analyzed using Raman Spectroscopy to determine cell distribution and characteristics as well as fibroblast activity. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Characterization |