| Abstract Scope |
Biological barriers often limit drug delivery by restricting transport to target tissues. This lecture presents electrochemical strategies that actively program drug transport using iontophoresis. First, I will introduce a wireless implantable dual-phoretic platform integrating electrophoretic drug release with iontophoretic tissue penetration, enabling spatiotemporally controlled delivery. The system improves drug penetration into solid tumors, enhances intratumoral distribution, increases therapeutic efficacy, and reduces systemic toxicity. I will then present a wearable extension of this concept that combines self-powered electrochemical actuation with a synchronized electrochromic indicator for real-time visualization of delivered dose. This platform enhances transdermal drug delivery while improving usability without external electronics. Together, these technologies demonstrate how electrochemical engineering can overcome biological transport barriers and enable efficient, user-friendly, and sustainable therapeutic delivery. |