| Abstract Scope |
This talk will provide an overview of multifunctional scaffolds that enable unique bio-engineering advances such as sculptured implants or bio-detection platforms. Bio-scaffolds are expected to not only provide structural support and infiltration of bioactive medium (molecules, gels, or cell-culture media), but also create a suitable nano-environment for the biological entities to thrive. An overview of current research in this field will be followed by discussion of multi-scale and multifunctional scaffolds being investigated in our laboratory. Our focus is on bio-inspired 3D architecture that can be subsequently functionalized with coatings or nanoparticles for specific applications. Larger porous substrates are covalently attached with arrays of one-dimensional nanotubes that mimic microvilli and brush borders in the living body. These in-turn support specific functional entities while providing ultra-high solid-fluid interaction area. Design, fabrication and characterization of such materials and their interaction with selected biofluids (water, gels, cell lines and pollutants) will be discussed. |