About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biomedical Materials and Devices: From Laboratory to Market
|
| Presentation Title |
Designing optimal preconditioning for in vitro cardiovascular pacing lead testing |
| Author(s) |
Cindy Xu, Tauheed Ahmed, Chase Kulsakdinun, Emilio Blythe, Justin Zimmerman, Janet L. Gbur |
| On-Site Speaker (Planned) |
Janet L. Gbur |
| Abstract Scope |
In vivo degradation of transvenous lead outer jackets alters their mechanical behavior during clinical extraction. To simulate the active immune foreign body response driving this process, this time-series study quantified the accelerated degradation rates of seven polyurethane and silicone jacket materials. Paired specimens of each material were maintained at 37°C in either an oxidative Fenton’s reagent (0.1M CoCl<sub>2</sub> in 20% H<sub>2</sub>O<sub>2</sub>) or a phosphate-buffered saline control. Every 3–4 days, solutions were refreshed and 2 cm segments were harvested. Optical microscopy, scanning electron microscopy, and laser profilometry characterized surface morphology and roughness. Attenuated total reflection Fourier transform infrared spectroscopy was used to analyze changes in the functional groups where peak intensities were used as a proxy to indicate that oxidation had occurred. Ultimately, this study aims to identify an optimal soaking duration that replicates clinical explant degradation, establishing a standardized preconditioning protocol to enable more realistic lead extraction testing procedures. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Characterization, Polymers, Biomaterials |