About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Effects of Mixing Conditions and Additives on Precipitation and Stability of Amorphous Calcium Phosphate |
| Author(s) |
Özgür Gülmez, Eren Demirbilek, Şeniz Uçar |
| On-Site Speaker (Planned) |
Özgür Gülmez |
| Abstract Scope |
Amorphous calcium phosphate (ACP) plays a crucial role as a transient precursor in calcium phosphate (CaP) mineralization, which underlies the formation of bone and dental tissue. Despite its biological significance, ACP’s rapid transformation to crystalline phases in aqueous environments limits its practical use. This study investigates ACP stabilization via controlled titration experiments that enable simultaneous monitoring of solution chemistry and solid-phase evolution. Three mixing routes—Ca-to-P, P-to-Ca, and simultaneous addition—were explored alongside the effects of citrate and bovine serum albumin (BSA) as stabilizing additives. In situ measurements of pH and Ca²⁺ activity were combined with XRD, Raman, FTIR, SEM, TEM, and TGA for structural and morphological analysis. ICP-OES and TGA were also used to evaluate Ca/P ratios and hydration states. Results reveal that both mixing sequence and additive presence significantly affect ACP’s lifetime and its transformation into hydroxyapatite. These findings provide mechanistic insight into precursor-mediated CaP formation under synthetic conditions. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Ceramics |