| About this Abstract | 
   
    | Meeting | 2025 TMS Annual Meeting & Exhibition | 
   
    | Symposium | AI/Data Informatics: Computational Model Development, Verification, Validation, and Uncertainty Quantification | 
   
    | Presentation Title | Deep Learning-Based Image Denoising for Enhanced CT Image Reconstruction | 
   
    | Author(s) | Parisa  Asadi, Zeyu  Zhou, Andriy  Andreyev, Matthew  Andrew | 
   
    | On-Site Speaker (Planned) | Andriy  Andreyev | 
   
    | Abstract Scope | ges arise from inherent image noise. This study evaluates DeepRecon Pro, a deep learning-based noise-to-noise image reconstruction method, using a digital twin of the Shepp-Logan phantom to simulate varied acquisition conditions. The Deep-Recon model processes projection images or reconstructed volumes to yield enhanced projections or reconstructions, respectively. Employing cone-beam geometry with simulated Poisson noise levels and reduced projections, Deep-Recon Pro utilizes a U-Net architecture to suppress noise and improve image fidelity compared to methods like FDK and non-local means (NLM). The latest version integrates synthetic priors and a two-stage training process, effectively introducing a matching noise model during training. Quantitative metrics, including mean square error (MSE) and structural similarity index (SSIM), underscore its superior performance. Our results demonstrate that Deep-Recon significantly enhances CT image quality, offering faster, more accurate reconstructions crucial for industrial and scientific applications demanding high precision and efficiency. | 
   
    | Proceedings Inclusion? | Planned: | 
 
    | Keywords | Machine Learning, Characterization, Modeling and Simulation |