Synthesis, Characterization, Modeling and Applications of Functional Porous Materials: Poster Session
Sponsored by: ACerS: Engineering Ceramics Division, ACerS: Electronics Divisions
Program Organizers: Lan Li, Boise State University; Winnie Wong-Ng, National Institute of Standards and Technology; Kevin Huang, University of South Carolina

Tuesday 4:45 PM
November 3, 2020
Room: Poster Hall
Location: MS&T Virtual

Session Chair: Winnie Wong-Ng, National Institute of Standards and Technology


Development of Nanostructured Vycor Glass Microspheres for Doxorubicin Administration: Bryan Escalante Castro1; Yanina Martinez1; Guillermo Zampieri1; Yrina Viatela1; 1Natinal Atomic Energy Comission
    In the present work, nanostructured porous SiO2 microspheres were developed for future drug release applications of doxorubicin. The glass has a nominal composition of 65.6SiO2 ·27.8 B 2 O 3 ·6.0Na 2 O·0.6Al 2 O 3 weight percent. Microspheres with a regular morphology and 25-35µm size were made by flame spheroidization method. The porous microspheres were obtained by a thermal separation treatment at 660°C for 6 and 10 hours so two immiscible phases were obtained one is rich in silica and the other one is rich in boron and sodium. After the lixiviation for 2 and 4 days, SEM images showed a greater interconnectivity of the pores as the phase separation time increased. The composition is mostly SiO2 studied by EDS and XPS Spectrofluorimetry of intensity vs concentration of doxorubicin showed a LogNormal distribution in deionized water. These results are important to relate release studies and pi-stacking of the drug.