Advanced Functional and Structural Thin Films and Coatings: Multifunctional Biomaterials, Innovative Approaches to New Concepts and Applications I
Sponsored by: TMS Functional Materials Division, TMS: Thin Films and Interfaces Committee
Program Organizers: Adele Carrado, University of Strasbourg; Ramana Chintalapalle, University of Texas at El Paso; Gerald Ferblantier, University of Strasbourg - IUT LP / ICube Laboratory - CNRS; Nancy Michael, University of Texas at Arlington; Karine Mougin, Cnrs, Is2m; Heinz Palkowski, Clausthal University of Technology; Nuggehalli Ravindra, New Jersey Institute of Technology; Vikas Tomar, Purdue University

Wednesday 8:30 AM
March 17, 2021
Room: RM 19
Location: TMS2021 Virtual

Session Chair: Adele Carrado, Université de Strasbourg IPCMS


8:30 AM  Cancelled
Bio-inspired Nano- and Microstructured Surfaces: Hendrik Hoelscher1; 1Karlsruhe Institute of Technology
    Nature developed fascinating phenomena through evolution in millions of years. Many of these served as inspiration for engineers to develop a large variety of products ranging from airplanes to algorithms for navigation systems. Of special interest are natural nano- and microstructured surfaces which can be found on a large variety on plants as well as insects and reptiles. In many cases, they assist for several purposes ranging from coloration and thermoregulation to self-cleaning and control of friction. Recent advances in nanofabrication allows the fabrication of bio-inspired surfaces inspired by the natural prototypes. In my talk, I will present recent bio-inspired surfaces which cause structural color, advance frictional properties, replace white TiO2 pigments, improve coatings of photo-voltaic modules, and allow self-cleaning.

9:10 AM  Invited
TiN and DLC Coated Medical Grade Polyurethane (PUR) for Controlled Surface Degradation and Improved Mechanical Properties: Maren Fossum1; Mohammad Ibrahim1; Javier Sanchez2; Christoph Burgstaller3; Emma Strömberg4; Gunilla Björling5; Ragnhild Aune1; 1Norwegian University of Science and Technology; 2Danderyd Hospital at Karolinska Institute ; 3TCKT - Transfercenter für Kunststofftechnik GmbH; 4KTH Royal Institute of Technology; 5The Swedish Red Cross University College
    Central Venous Catheters (CVCs) are one of the most frequently used medical devices in a hospital setting today. The device, often made from medical grade polyurethane (PUR), is prone to complications such as thrombosis, bloodstream infections and mechanical failures. With the aim of targeting enhanced chemical and mechanical behaviour of CVCs, as well as improved surface properties, the effect of TiN and DLC nanocomposite coatings deposited onto medical grade PUR substrates (aliphatic carbothane with 20 wt-% barium sulphate loading) have been investigated. The thickness and topography of the coatings, as well as their adhesion performances were evaluated together with their overall chemical stability, hydrophobicity, hemocompatibility, stress loading and scratch resistance. Both coatings proved to decrease the rate of degradation under in-vitro environmental conditions, as well as offer reduced risks of blood coagulation. Furthermore, improved mechanical properties were confirmed, which potentially could prolong the service lifetime of CVCs during clinical use.

9:40 AM  Invited
Multimodal Flexible Optoelectronic Devices for Colocalized Electrophysiology and Optophysiology: Luyao Lu1; 1George Washington University
    Recent advances in new materials, electronic devices, and fabrication techniques have allowed optoelectronic devices to interface with biology and contribute significantly to the progress in basic research as well as clinical medicine. In this talk, I will introduce a novel class of flexible, multimodal optoelectronic devices that combines high-performance metal nanostructure-based transparent microelectrodes with microscale light-emitting diodes for simultaneous electrophysiology and optophysiology at the same anatomical sites. We envision this unique technology will open up new windows to interrogating complex biological systems at multiple scales by enabling mapping the dynamics of perturbed cell populations under programmed modulation and correlating cellular responses to behavior.

10:10 AM  Invited
Structural and Biological Properties of Silicon-incorporated Diamond-like Carbon Coatings: Roger Narayan1; 1University of North Carolina
    Diamond-like carbon coatings are being evaluated for many types of biotechnology and biomedical applications due to their exceptional mechanical, chemical, and biological properties. We evaluated the adhesion, mechanical, chemical, and biocompatibility properties of silicon-incorporated diamond-like carbon coatings. The effects of argon and oxygen plasma treatments on coating adhesion were also examined. Silicon-incorporated diamond-like carbon coatings were deposited on fused silica using plasma enhanced chemical vapor deposition. The plasma-treated coatings showed greater hydrophilicility than the unmodified silicon-incorporated diamond-like carbon coating. Atomic force microscopy and profilometry studies showed that the plasma treatment increased coating roughness and coating roughness. The plasma treatment was also shown to reduce the adhesion of the coating. The unmodified and plasma-treated coatings were shown to be biocompatible. The results of this study indicate that plasma enhanced chemical vapor deposition produced diamond-like carbon coatings with appropriate adhesion, mechanical, chemical, and biocompatibility properties for biotechnology and biomedical applications.

10:40 AM  
Silicone Breast Implants: Grafting of a Bioactive Polymer to Improve the Bio-integration: Mylan Lam1; Vivien Moris1; Vincent Humblot2; Véronique Migonney1; Céline Falentin-Daudré1; 1Université Sorbonne Paris Nord; 2Université Bourgogne Franche-Comté
     Lately, the emergence of breast implants associated anaplasic large cell lymphoma (BIA-ALCL) has led to the reconsideration of breast implants safety. Characterized by a tightened capsular contracture, it causes pathological fibrosis and skin deformations which require the removal of the implant. The origins of BIA-ALCL remain unknown but bacterial infections appear as the main explanation. The surface’s non-wettability contributes to poor cell adhesion and non-specific protein adsorption. The presence of methyl groups makes the surface chemical modifications challenging. Recently, our team has developed a simple way to graft a hydrophilic and bioactive polymer bearing sulfonate groups on silicone surfaces only by using UV. Characterization of the grafting was done by using colorimetric analysis, contact angle measurements, XPS, and AFM. Biologically, the polymer has already shown anti-bacterial properties with an anti-adhesive action on titanium surfaces and polymers for orthopedic applications. The same studies are currently under investigation on breast implants surfaces.

11:00 AM  Keynote
Determining the Interaction between Porous Titanium and Adhesion of a Bioactive Coating: Holly Martin1; Patrick McWhorter1; Arthur Kasson1; Snjezana Balaz1; 1Youngstown State University
    Chitosan is a bioactive polymer and previous research has focused on creating a bond between polished titanium and chitosan through the use of linker molecules. A smooth surface, though, only gives a flat surface for bone cells to attach. For improved osseointegration, a rougher surface with small pores would provide more locations for bone cell attachment and growth. The research presented here will explore how porous titanium affects the multi-step process of bonding chitosan to titanium. These steps will be monitored using x-ray photoelectron microscopy, contact angle, and surface mapping to determine how the porosity is modified by the linker molecules and the final chitosan coating.