Bio-Nano Interfaces and Engineering Applications: Bio-Nano Interfaces I
Sponsored by: TMS Functional Materials Division, TMS Structural Materials Division, TMS: Biomaterials Committee
Program Organizers: Candan Tamerler, University of Kansas; Kalpana Katti, North Dakota State University; Hendrik Heinz, University of Colorado Boulder; Terry Lowe, Colorado School of Mines; Po-Yu Chen, National Tsing Hua University
Wednesday 8:30 AM
February 26, 2020
Room: Vista
Location: Marriott Marquis Hotel
Session Chair: Candan Tamerler, University of Kansas; Hendrik Heinz, University of Colorado Boulder
8:30 AM Keynote
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO: Carole Perry1; 1Nottingham Trent University
The synthesis of materials with complex structures and well-defined properties is a central focus of the ‘Directed assembly of extended structures with targeted properties’ grand challenge, given their importance to economic growth and role in addressing key societal challenges. In materials produced by nature, I.e. biominerals: proteins, lipids and carbohydrates act as agents to control both formation and the physio chemical properties of the composite materials that result. Taking inspiration from nature we extend the ideas of molecular recognition, ads/desorption to the formation of commercially relevant materials. Using examples of MOFS and composites of ZnO and gold we showcase how peptides can be used to tailor the structures formed, In all our studies we use a wide range of experimental techniques to characterise our (bio) materials and measure molecular behaviour at interfaces. The research presented will include new methods being developed specifically to probe such interactions.
9:00 AM
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules: Vadim Kessler1; 1SLU
Metal oxide nanoparticles (NP) are common in the environment originating on weathering of minerals both in marine and freshwater environments and in soil. Their effects on living organisms are important in the view of complex surface chemistry and enhanced surface to volume ratio. In the present contribution three major effects of NP will be considered – (1) their role in mediating interactions between soil microorganisms and plant roots with strong contribution to biofilm formation, (2) the catalytic effects in plant tissues, where NP can act as nanozymes, and (3) specific protein adsorption, resulting in formation of scaffolds for tissue regeneration. Major tools in this work have been X-ray single crystal, NMR and electrospray mass-spectrometry studies of oxide “cluster” models bearing selected biomolecular ligands.
9:30 AM Keynote
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming: Mohan Edirisinghe1; Ayda Afshar1; 1University College London
Fine polymeric fibers offer numerous advanced technology applications, particularly in healthcare, e.g. filters which can trap microbes in hospital water and ventilation systems. One simple and scalable fiber forming method is pressurized gyration, where a drum containing a polymeric solution is spun at high speed while gas pressure is streamed into the vessel generating fibers through numerous millimetre size orifices on the drum. Seven years after its conception, many variants of it have been created, e.g. pressure coupled infusion gyration (Advanced Science News 23 July 2018). The key factor has been the ability to tinker with the bio-nano interface of fibers and other morphologies. This has resulted in some remarkable advancements, e.g. in tackling pre-term birth and enhanced treatment for diabetes. The process has now advanced to the manufacture of core-sheath fibers (Materials & Design Volume 178, 2019, 107846) and developments in this area will also be discussed.
10:00 AM Break
10:15 AM Invited
Chiral Inorganic Nanostructures: Nicholas Kotov1; 1University of Michigan
Early observation of strong circular dichroism for individual nanoparticles (NPs) and their assemblies have developed into a rapidly expanding field of chiral inorganic nanostructures. The chiral inorganic nanostructures encompass sophisticated constructs from metals, semiconductors, ceramics, and nanocarbons with multiple chiral geometries with characteristic scales from Ångströms to microns. Many of them are formed spontaneously from polydispersed building blocks, which enables their structural and functional engineering over a broad range geometries and optical properties. This talk will address (1) the mechanisms of chirality transfer in inorganic materials, (2) the origin of the uniquely high values of optical anisotropy, (3) the fundamental challenges of multiscale chirality observed in nanostructures, and (4) physicochemical differences and similarities with chiral supramolecular, liquid crystal, and biological systems. Technological potential of chiral NPs assemblies is expected for real-time modulation of the polarization of light and enantioselective catalysis. The first realization of CD spectroscopy in terahertz spectral window will be demonstrated.
10:45 AM Invited
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials: Anna Pohl1; Taifeng Wang1; Wei Huang1; Michiko Nemoto2; David Kisailus1; 1University of California Riverside; 2Okayama University
Natural systems have evolved efficient strategies to synthesize composites from a limited selection of available materials that often exhibit exceptional mechanical properties that are frequently superior to those exhibited by engineering materials. These systems have accomplished this by establishing controlled synthesis and hierarchical assembly of nano- to micro-scaled building blocks. This requires organic that is used to transport mineral precursors to organic scaffolds, which not only precisely guide the formation and phase development of minerals, but also significantly improve the mechanical performance of otherwise brittle materials. Here, we investigate the formation of heavily crystallized radular teeth the chitons, a group of elongated mollusks that graze on hard substrates for algae. From the investigation of synthesis-structure-property relationships in these unique organisms, we are now developing and fabricating multifunctional engineering materials for energy conversion and storage. We discuss the crystallization of these materials and their subsequent impact on performance.
11:15 AM Invited
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level: T. Venus1; T. Meyer1; J. Böttner1; C. Merker1; V, Calcagno1; J. Keller2; R. Landsiedel2; D. Schwotzer3; O. Creutzenberg3; M. Moro4; S. Moya4; J. P. Longo5; L. Muehlmann5; Irina Estrela-Lopis1; 1University Leipzig; 2BASF SE; 3Fraunhofer Institute ITEM; 4CIC biomaGUNE; 5University of Brasilia
The degree and the mechanism of uptake, localization and distribution of nanomaterials (NMs) in cells and organs are major issues concerning toxicity and risk assessment of the novel products. Furthermore, the application of NMs as devices for diagnostic and therapeutic purposes requires monitoring of their interaction with biomolecules. The translocation of NMs across plasma membranes, their quantification and interaction with metabolic relevant cellular elements and biomolecules were studied in in vitro as well in vivo by means of label-free imaging methods based on element and molecule analysis. A quantitative analysis of minor and trace elements on the surface of NMs within single cells were performed and correlated with the cellular adverse response. Furthermore monitoring NM uptake, their bioprocessing, interaction with biomolecules and induced biochemical changes as well diagnostic and prediction of adverse effects were studied in living cells by means of confocal Raman microspectroscopy, cluster analysis or principle component analysis.