Advanced Biomaterials for Biomedical Implants: Advanced Biomaterials for Implants II
Sponsored by: TMS Functional Materials Division, TMS: Biomaterials Committee
Program Organizers: Tolou Shokuhfar, University of Illinois at Chicago; Jing Du, Pennsylvania State University
Wednesday 2:00 PM
March 22, 2023
Room: Sapphire 400B
Location: Hilton
Session Chair: Thomas Vinoy, University of Alabama at Birmingham; Du Jing, Pennsylvania State University
2:00 PM Invited
Application of Magnetic Iron Oxide Nanostructures in Drug Delivery: A Compact Review: Inono C. Omoruyi11; Jeffery Omoruyi2; Oscar Aghedo3; Ukeme Archibong4; Ikhazuagbe Ifijen2; 1Department of Chemistry, University of Benin, Benin City, Edo state, Nigeria; 2Rubber Research Institute of Nigeria; 3University of Benin; 4 University of Benin
Magnetic iron oxide nanoparticles (IONs) stand out among a plethora of drug nanocarriers as sturdy nanoplatforms due to exceptional magnetic and biological properties, which allow them to achieve significant drug loading as well as targeting capabilities. These applications necessitate accurate nanoparticle design in terms of numerous characteristics that must be evaluated in tandem to achieve maximum therapeutic efficacy. This concise overview summarizes recent advances in the roles of untreated and modified iron oxide nanoparticles for drug delivery. These modifications included chitosan, poly(vinylpyrrolidone), poly(vinyl alcohol), poly(lactic-co-glycolic acid), and poly(ethylene glycol). One of the key areas of research in the targeted drug delivery domain is the invention of nanocarriers that allow for efficient delivery of therapeutic chemicals to specific sites. Drugs loaded onto iron oxide nanoparticles can be efficiently guided and selectively delivered to selected sites by precisely altering the structural features of the nanoparticles.
2:30 PM Cancelled
Design, Characterization, and In Vitro Corrosion Properties of New near β Ti- Nb -Ag Alloy for Bio Implant Applications: Mohamed Hussein1; Arumugam Kumar1; Mohamed Abdul Azeem1; Ahmad Sorour1; Saravanan Sankaran1; 1King Fahd University of Petroleum and Minerals
Ti-6Al-4V has been employed in implant applications, although V and Al are potentially hazardous, especially for long-term implants. Therefore, in this work, using d- electron alloy design and molybdenum equivalence, a new near β Ti-Nb-Ag alloy was designed from nontoxic and biocompatible elements. The designed alloy was synthesized from elemental powders using mechanical alloying under an argon atmosphere, then the synthesized powder was compacted and sintered. The synthesized and sintered alloy's structure and microstructure were investigated. The mechanical properties were assessed using micro indentation. The antibacterial activities of the developed alloy were tested against gram-negative and gram-positive bacteria. The in vitro corrosion properties were studied in simulated body fluid to assess the potential of the designed alloy for bio implant applications. ACKNOWLEDGEMENT The authors would like to acknowledge King Fahd University of Petroleum & Minerals and Interdisciplinary Research Center for Advanced Materials for the provided support under Grant # INAM2108
2:50 PM
Finite Element Analysis of Partially Biodegradable Ti-PGA Composite Implants Assembled with Bone Fractures: Hassan Mehboob1; 1Prince Sultan University
Few researchers have developed porous biomaterials to tackle the stiffness of the bulk materials and offer low stiffness to match the properties of the bones. Finite element models of body-centered cubic (BCC) porous structures with a porosity of 70% are filled with polyglycolic acid (PGA) to prepare the composites. The composite of the Ti-PGA BCC structure is modeled in SOLIDWORKS. The composite cubes were imported in ABAQUS to simulate the compressive properties. A fracture gap size of 3 mm was introduced and a number of bi-cortical screws are used to assemble the fractured bone and implants (composite and dense titanium). The results shows that the BCC composite cube gave lower mechanical properties as compared to the dense titanium stems. The stiffness of the healed fracture increases in the case of larger size of the callus.
3:10 PM
Manufacturing of Mg Wires with Optimized Properties for Biomedical Applications: Wahaaj Ali1; Leon Tillmann2; Guillermo Domínguez3; Muzi Li1; Mónica Echeverry-Rendón1; Tim Mayer2; Carlos González3; Javier Llorca3; Alexander Kopp2; 1IMDEA Materials Institute; 2Meotec GmbH; 3IMDEA Materials Institute & Technical University of Madrid
Bioresorbable magnesium fibers (filaments or wires) have a large potential for biomedical applications, such as wound closure, orthopedics, bioresorbable electronic sensors, nerve repair, etc. WE43 Mg alloy wires were manufactured by successive cold drawing and annealing steps at high temperature to reach an optimum combination of mechanical properties. Afterwards, they were surface-modified by plasma electrolytic oxidation using a novel continuous process. The microstructure, mechanical properties and degradation rate in simulated body fluid as well as the cytocompatibility of the wires was assessed by means on vitro tests in simulate body fluid. It was found that the presence of a compact oxide layer of a few µm in thickness was critical to avoid localized corrosion, maintain mechanical properties for longer times and limit the reactivity of the wires to ensure excellent biocompatibility.
3:30 PM Break
3:50 PM
Developing Strong and Ductile TWIP Zr-based Alloys for Cardiovascular Stent Application: Junhui Tang1; Philippe Vermaut1; Frédéric Prima1; Fan Sun1; 1Chimie-ParisTech
Good combination of strength and ductility, superior biocompatibilities and sufficient radio-opacity are desirable properties for materials to make cardiovascular stents. Zirconium is interesting for stent application due to its good corrosion resistance, low magnetic susceptibility and superior biocompatibility. However, pure Zr and conventional Zr alloys are not suitable for thin-strut stent design due to their limited strength or ductility. In the present work, new beta-metastable Zr alloys are developed to combine high strength and good ductility. Among the studied alloys, the ones exhibiting Twinning Induced Plasticity (TWIP) effect show important improvements of strength, strain-hardening rate and uniform elongation. Metallographical investigations, including in-situ electron backscattered diffraction (EBSD) mapping and transmission electron microscopy (TEM) observations under tensile load, are conducted to clarify the deformation mechanisms. Corrosion susceptibility assessment, biocompatibility characterization and stent prototyping are planned to evaluate the new TWIP Zr alloys for stent application.