Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments: Poster Session
Program Organizers: Thomas Dziubla, University of Kentucky; Christopher Siedlecki, Penn State College of Medicine; Jeffrey Capadona, Case Western Reserve University; Lynne Jones, Johns Hopkins Orthopaedics

Monday 5:00 PM
October 10, 2022
Room: Ballroom BC
Location: David L. Lawrence Convention Center


C-6: Cell-scaffold Interactions in Bijels-derived Porous Membranes: Haoran Sun1; Min Wang1; 1University of Hong Kong
    Bicontinuous interfacially jammed emulsion gels (“bijels”) consist of two interpenetrating continuous phases, with each being filled with a liquid. Biocompatible bicontinuous bijels-derived structures may be made, which can have interconnected channels that are desirable in tissue engineering as the channels can provide space for cell proliferation and migration. A solvent transfer-induced phase separation-based technique was developed by previously, which could make biocompatible bijels-derived hybrid structures. In this study, bijels-derived porous hexanediol diacrylate membranes of different channel sizes (20-100um) were fabricated for studying cell behaviors on/in scaffolds. Human dermal fibroblasts and osteoblastic MC 3T3 cells were cultured separately on bijels-derived porous hexanediol diacrylate for up to 28 days. Both cells showed high cell viability and good cell proliferation on scaffolds. Cells could migrate and proliferate well in channels of membranes having average channel sizes larger than 50um. In membranes with smaller channel sizes, cells only exhibited partial migration into channels.

C-7: Modeling a Portable Ventilator Design for Optimal Performance: Yafeng Li1; Lei Wang1; Peng Yi1; Francisco Rodriguez2; Jing Zhang2; 1Tiangong University; 2Indiana University – Purdue University Indianapolis
    In this work, a portable ventilator design for patients, including those with the Covid, is modeled. The material properties and the geometry of the ventilator components are selected based on the assembled ventilator prototype. First, the mechanical motions of the ventilator are optimized using an optimization code. Then the 3D model of the ventilator is constructed and simulated using finite element programs. Specifically, the respiratory airbag is focused for the coupled motion between the flexible body and fluid mechanics. The results show that the pressure and fluid velocity distributions of the respiratory airbag in the operation conditions can be optimized based on the patient’s breath needs. Additionally, a theoretical model for the rigid body dynamics is employed to compare against the finite element models.

C-8: Osteoblast Cell Interaction with Iron-deposited Titanium for Orthopedic Applications : Dexter Kling1; Paige Bothwell1; Sahar Vahabzadeh1; 1Northern Illinois University
    Surface modification of titanium (Ti) and its alloys is a common method to improve bone tissue formation and integration for orthopedic and craniomaxillofacial applications. In current work, we used combination of alkali-treatment and physical vapor deposition to roughen the surface and deposit iron (Fe) on the surface of titanium at different thicknesses. Fe plays an important role in bone metabolism and remodeling, and is believed to enhance osteogenesis. The optimized thicknesses of 150 Å and 500 Å were selected for biological characterization. We found that alkali-treatment using 10 M NaOH medium increases the surface roughness of Ti, significantly. Further modification by Fe deposition did not alter the network structure obtained by alkali-treatment and Fe was uniformly distributed on the surface. Our results also showed that alkali-treatment enhances the VEGF expression in Ti. Both alkali-treatment and Fe deposition change the osteoblast cell proliferation and differentiation, which depends on Fe concentration.