2017 Symposium on Functional Nanomaterials: Emerging Nanomaterials and Nanotechnology: Nanomaterials for BT Applications
Sponsored by: TMS Functional Materials Division, TMS: Nanomaterials Committee
Program Organizers: Jiyoung Kim, University of Texas; Stephen McDonnell, University of Virginia; Chang-Yong Nam, Brookhaven National Laboratory; V. U. Unnikrishnan, The University of Alabama; Nitin Chopra, The University of Alabama

Wednesday 8:30 AM
March 1, 2017
Room: Pacific 24
Location: Marriott Marquis Hotel

Session Chair: Stephen McDonnell, University of Virginia; Lanxia Cheng, The University of Texas at Dallas

8:30 AM  
Probing Osteogenic Cell Functionality on Architected Nanolattices with Stiffness Spanning the Low Megapascal Region: Alessandro Maggi1; 1California Institute of Technology
    Creating prostheses that lead to optimal bone remodeling has been a challenge for more than two decades because of a current lack of knowledge of mechanotransduction in three-dimensional environments. Limitations in traditional fabrication and characterization techniques have limited our understanding of the effects that pore size and mechanical cues have on cell behavior. Pore dimensions smaller than 100μm in 3D scaffolds with stiffnesses higher than a few hundred KPa have not been achieved yet. Recent advances in multiphoton lithography allowed us to create 3-dimensional architectures with tunable porosity and variable local and global stiffnesses that reached a region spanning from 2 to 9 MPa. Our nanolattices enabled us to explore how scaffold mechanical properties influence osteoblasts’ functionality in a microenvironment that simulates conditions found in natural bone. Understanding the lower and upper stiffness boundaries for which osteogenic cell functionality is preserved has the potential of leading to better orthopedic implants.