Porous Materials for Biomedical Applications: Poster Session
Sponsored by: ACerS Bioceramics Division
Program Organizers: Usman Liaqat, National University of Sciences and Technology; Chuanbin Mao, University of Oklahoma; Mingying Yang, Zhejiang University
Tuesday 12:00 PM
October 19, 2021
Room: Exhibit Hall B
Location: Greater Columbus Convention Center
P2-7: 3D Printing Seamless Hydrogels for In-vivo Pressure Sensing Devices: Ashwin Velraj1; Jeffrey Bates1; 1University of Utah
Novel additive manufacturing technologies have inspired researchers to explore materials that can deliver desired functionalities within a complicated design structure. The use of custom biomaterials as inks for 3D-printing has been explored to curate features that are otherwise near-impossible to obtain through conventional methods where structural delamination causes device failures. Here, we investigate the customization of Stereolithography (SLA) printing of polymer bio-inks using UV-photo-crosslinking mechanism to obtain a seamless single walled hydrogel tube construct with cross-sectional diameters ranging from 3000 to 100 microns. An aqueous composition of acrylated gelatin and poly(ethylene glycol) with biocompatible photo-initiators sensitive to 405 nm UV radiation are explored as bioinks for SLA 3D-printing. Such material compositions are great candidates in implantable device fabrication that react to bodily changes in a controlled manner. Further development of these hydrogel tubes by embedding pressure sensing circuitry, allows dynamic measurement of pressure changes within the eye to monitor glaucoma.
Poster
P2-8: In vitro Investigation and Characterization of Resorption and Degradation Behavior of X-Ca-alginate Aerogels for Tissue Scaffold Applications: Martina Rodriguez Sala1; Grigorios Raptopoulos2; Patrina Paraskevopoulou2; Firouzeh Sabri1; 1The University of Memphis; 2National and Kapodistrian University of Athens
Tissue regeneration is an intricate process facing many challenges. Studies have focused on customized-scaffolds to direct cell behavior and facilitate regeneration. Controlled biodegradability offers advantages compared to non-degradable scaffolds. Primarily, controlled resorption and degradation creates space for new tissue to grow. In the present study, polyurea-crosslinked calcium alginate aerogels (X-Ca-alginate aerogels) are investigated as a novel degradable biomaterial. Aerogels are a new class of biomaterial and recent studies have shown that not only are aerogels biocompatible but they also accelerate nerve growth and as such are highly desired as a neural prosthetic. X-Ca-alginate aerogels are biobased polymers formed by polysaccharides and strengthened though polymer-crosslinking, providing mechanically strength to support biomedical applications. To study the biomedical applications of X-Ca-alginate aerogels, extracellular matrix (ECM) proteins were used to coat the aerogel, and mammalian cells were cultured on the aerogels. The interaction between ECM, cells and X-Ca-alginate aerogels were observed and reported.