Biological Materials Science: Poster Session
Sponsored by: TMS Functional Materials Division, TMS Structural Materials Division, TMS: Biomaterials Committee
Program Organizers: David Restrepo, University of Texas at San Antonio; Steven Naleway, University of Utah; Jing Du, Pennsylvania State University; Ning Zhang, Baylor University
Wednesday 5:30 PM
March 17, 2021
Room: RM 21
Location: TMS2021 Virtual
Session Chair: David Restrepo, The University of Texas at San Antonio; Jing Du, Penn State University
A Novel Cardiac Patch for Treating Myocardial Infarction: Juan Sebastian Rincon Tabares1; Juan Camilo Velasquez1; Hayden Bilbo1; Hai-Chao Han1; David Restrepo1; 1The University of Texas at San Antonio
Myocardial infarction (MI) is the most common heart disease. MI leads to scar and aneurysm in the heart wall that deteriorating the pump function and leads to heart failure. Currently,cardiac patches (CPs) are used to strengthen the aneurismal scar tissue to improve cardiac function. Current CPs have two major limitations: (i) CPs can only provide passive support to the scar tissue and no ability to assist heart contraction,(ii) The human heart is highly anisotropic. Our objective was to develop a smart material that could generate shrinkage under tension. Then, it can assist heart contraction and conform better to the native heart movements and mechanical properties. An analytical approach with computational verification was proposed to explore a potential design of architectural material that shrinks under tensile forces. Finally,using physical geometries, the architectural material models have been validated by digital image correlation (DIC). The material shows negative strain values of over 30%.
Bone-Mimetic β-TNTZ Alloy for Osteointegration and Antibacterial Property: A Rat Animal Model: Ya-Ching Yu1; Shih-Jie Lin2; Ta-Jen Yen1; 1National Tsing Hua University; 2New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, Taiwan
Recently, orthopedic implants focus on the effect of osteointegration and prevention of implant-associated infections (IAI). Anodic oxidation was applied to β-type Ti-28Nb-11Ta-8Zr (TNTZ) for fabricating crystallized nanoporous oxide (NPTNTZO(c)) on the surface, which demonstrating bone-mimetic young’s modulus, biocompatibility, and antibacterial capability in previous study. However, in-vivo test is a crucial part for bone-related implants. In this study, the rats were randomly divided into NPTNTZO(c) and control group for 4,8, and 12 weeks. After sacrificed, NPTNTZO(c) exhibited larger ultimate pull-out load in biomechanical test. Besides, 8 and 12-weeks groups even exceeded 200N. The reason is that rough surface could enhance bone ingrowth and osteoconductive property. The results of histological and micro-CT analysis also manifested corresponding performance. Next, NPTNTZO(c)/AgNPs, carried with silver nanoparticles into nanostructure, could increase antimicrobial ability in vivo. In essence, NPTNTZO(c)/AgNPs show excellent osteointegration and resistance of bacterial infections with prospective clinical outcomes.
Strain Field Mining of Steady-state Tearing Fields in Thin Film, Heterogeneous Fiber Networks: Sarah Paluskiewicz1; Christopher Muhlstein1; 1Georgia Institute of Technology
Paper is a heterogeneous, anisotropic fiber network with ubiquitous applications. Its mechanical properties are deeply influenced by the network structure. We used digital image correlation as a non-contact, full-field method to characterize the progression of damage mechanisms in paper with double-edge notch tensile (DENT). Initially, crack growth accelerated then once the peak nominal stress was achieved, steady-state tearing prevailed until a final overload was achieved. At overload, when apparent crack length over width is projected to unity, there is non-zero nominal offset stress (8.0 MPa) due to fiber bridging. We found that the size and shape (3 mm oval) of the steady-state fracture process zone can be related back to the microstructural characteristics, specifically the floc size (3 mm). The remaining ligament (1.9 ± 1.4 mm) at overload typically remained less than the characteristic floc size.