Next Generation Biomaterials: Session III
Sponsored by: ACerS Bioceramics Division, TMS Biomaterials Committee
Program Organizers: Roger Narayan, University of North Carolina; Min Wang, University of Hong Kong; Shawn Allan, Lithoz America LLC
Wednesday 8:00 AM
October 20, 2021
Room: A224
Location: Greater Columbus Convention Center
Session Chair: Emiyl Lazarus, Rochester Institute of Technology; Hamdy Ibrahim, University of Tennessee Chattanooga; Sandra Musu Jusu, Worcester Polytechnic Institute
8:00 AM
Comparison of Various Post Coating Treatments on Plasma Sprayed HA Coatings: Manoj Mittal1; Tarun Goyal1; 1IK Gujral Punjab Technical University Jalandhar
Due to very high temperature of plasma in plasma spray coating techniques, some of the properties of HA powder gets deteriorated after spraying to generate coating. It is found from in-vitro studies conducted by many of the researches since it has been used as a coating material for biological applications that as sprayed coating lack some of the requirements which include Crystallization, porosity, surface roughness, refined crystallographic morphology, wide opened cracks. These properties need to be defined with respect to the usage of the implant (location), service life, dissolution/ absorption properties, load bearing capacity and many more. In this study, a comparison of various post coting treatments which includes, post coating heat treatment, stream treatment and cryogenic treatment is done to check the effect of these treatments on the desired properties of HA coating.
8:20 AM
Corrosion Assessment of Rare Earth Elements and Magnesium-based Nanocomposites for Bio-implant Applications: Moataz Abdalla1; Austin Sims1; Meysam Haghshenas2; Manoj Gupta3; Hamdy Ibrahim1; 1University of Tennessee at Chattanooga; 2University of Toledo; 3National University of Singapore
Magnesium alloys have been the focus of bio-implant research due to their preferable properties such as biocompatibility and low relative density. However, they show insufficient strength and fast degradation rates. Magnesium nanocomposites on the other hand offer a promising alternative to magnesium alloys owing to their higher strength, ductility, and corrosion resistance. In this work, the effect of adding different types of rare-earth oxide nanoparticles on the corrosion characteristics of magnesium-based nanocomposites has been studied for the first time. A combination of powder metallurgy, hybrid microwave sintering, and hot extrusion manufacturing processes were used to produce the nanocomposite parts. The electrochemical and immersion corrosion test results show that the addition of the rare-earth oxide nanoparticles, especially the samarium oxide (Sm2O3) nanoparticles results in improved corrosion behavior of the Mg-based nanocomposites, by reducing the corrosion rates, in addition to a significant enhancement in the mechanical and creep properties.
8:40 AM Invited
Hierarchical Hybrid Carbon Nanotube Enhanced Bioscaffolds for Wound Healing: Soham Parikh1; Wenhu Wang2; Tyler Nelson3; Courtney Sulentic1; Sharmila Mukhopadhyay2; 1Wright State University; 2The University of Maine; 3Wright-Patterson Air Force Base
Injuries involving skin cause a significant socioeconomic burden. In 2018 alone, such injuries required more than $28 billion for Medicare. Current wound healing scaffolds are limited in sterilization options, storage, and cell proliferation. In this study, we have investigated keratinocyte cell growth on Carbon Nanotube (CNT) enriched biocompatible carbon fabric as potential wound healing scaffolds. It was seen that these materials provide excellent biocompatibility for keratinocytes as shown by cytotoxicity, cell proliferation, and cell migration analyses. They also provide cytoprotection against environmental stressors such as Ultraviolet-B rays. One focus of this study was to understand if and how modification of these surfaces can be used to influence cell health and proliferation. Results show that cell proliferation mechanisms are impacted by functionalization that alters the CNT carpet length and the hydrophilic/hydrophobic behavior of nanotubes. These proof-of-concept studies indicate the strong future promise of adapting these bio-mimetic scaffolds for tissue engineering applications.
9:00 AM
In Vivo And In Vitro Evaluation of PLGA-PEG Microspheres Loaded with LHRH-Targeted Drugs for Effective Breast Cancer Treatment.
: Sandra Jusu1; John Obayemi1; Ali Salifu1; Chukwudalu Nwazojie2; Vanessa Uzonwanne1; Olushola Odusanya3; Winston Soboyejo1; 1Worcester Polytechnic Institute; 2African University of Science and Technology; 3Sheda Science and Technology Complex (SHESTCO)
This study focused on developing targeted drug systems to treat and prevent locally recurring TNBC tumors after surgical resection. In the study, we developed a blend of FDA-approved polylactic-co-glycolic acid-polyethylene glycol polymeric microspheres encapsulating targeted therapeutic agents. We functionalized these therapeutic agents with LHRH-Releasing hormone ligands. We prepared PLGA-PEG microspheres using solvent evaporation technique, characterizing them in terms of their physicochemical, structural, morphological, and thermal properties. The in vitro drug release was done at human body temperature and hyperthermic temperatures. Transient concentrations were measured using UV visible spectrophotometer. Kinetic and thermodynamic models were used to characterize the in vitro drug release from PLGA-PEG microspheres. This revealed a non-Fickian drug release, well-characterized by the Korsmeyer-Peppas model and thermodynamically non-spontaneous. Under in vitro and in vivo conditions, LHRH-conjugated drugs greatly reduced TNBC’s cell/tissue viability and prevented its loco-regional recurrence. Kaplan–Meier analysis revealed significantly extended survival for treated mice post-surgical tumor resection.
9:20 AM
Innovative Solutions to Produce Bioceramic Implants by 3D Printing: Kenna Ritter1; Peter Durcan1; 13DCERAM SINTO INC
3DCERAM has developed a unique 3D printing manufacturing process, based on laser stereolithography technology, to produce made-to-measure bioceramic cranial or jawbone implants. Enabling the production of implants with three-dimensional shapes in hydroxyapatite and tricalcium phosphates, materials widely renowned for their osteoconductive properties.Thanks to the unique process, 3DCERAM can produce bioceramic implants with porosity structured in three dimensions. The 3D printing process enables to control the location and geometry of porous areas and define a consistent diameter of pores.The clinical review made on more than 20 patients during 10 years for craniofacial surgery made by 3dprinting demonstrates:•Total biocompatibility of the materials produces by 3dprinting•Long term fixation and stability of the implant due to the bone growth into the porosity•A perfect aesthetic result for the cranioplasty reconstruction
9:40 AM
Synthesis of Three-dimensional Ceramic Microlattices by Aerosol Jet Nanoparticle Printing and their Use in Cancer Biomarker Detection: Bin Yuan1; Chunshan Hu1; Azahar Ali1; Rahul Panat1; 1Carnegie Mellon University
Three dimensional (3D) ceramic micro/mesoscale lattice structures are important for a wide range of technological applications. In spite of considerable progress in this area, the current processes suffer from control over dimensions at length scales below about a millimeter. In this research, we report an entirely new approach to synthesize complex 3D microengineered ceramic structures such as micro pillars and micro lattices by using Aerosol Jet (AJ) nanoprinting. Complex structures of zinc oxide with a minimum feature size of 30 um and having aspect ratios of up to 25:1 without any templating/support are demonstrated, thus filling an important gap in possible ceramic architectures. The structures show a shrinkage of 1-2% after sintering, leading to near-net-shape part fabrication. We demonstrate a device using AJ printed ceramic 3D structures where an electrochemical cell is used to detect Her2 breast cancer biomarkers by immobilizing antibodies on the rough and porous 3D ceramic surfaces.