Next Generation Biomaterials: Poster Session
Sponsored by: ACerS Bioceramics Division
Program Organizers: Roger Narayan, University of North Carolina; Sanjiv Lalwani, Lynntech, Inc.
Monday 5:00 PM
October 10, 2022
Room: Ballroom BC
Location: David L. Lawrence Convention Center
Session Chair: Roger Narayan, NC State University
C-2: 4D Printed Bilayer Vascular Grafts with Sustained Ionic Dissolution Products and Heparin Release for Rapid Endothelialization: Shangsi Chen1; Min Wang1; 1University of Hong Kong
The endothelial cell layer in blood vessels plays a crucial role in anticoagulation, transmitting biochemical signals and keeping blood vessels unobstructed. Rapid endothelialization of vascular grafts can prevent thrombosis and hyperplasia and promote blood vessel regeneration. In this study, shape-morphing bilayer vascular grafts with sustained ionic dissolution products (Mg2+ and SiO43-) and heparin release were fabricated via 4D printing and electrospinning. Shape-memory PDLLA-co-TMC and nanoclay were mixed and 4D printed into composite scaffolds, which served as one layer of the grafts. A layer of electrospun PDLLA-co-TMC fibers incorporated with PDA nanoparticles which encapsulated heparin was deposited on the composite scaffold layer, forming bilayer vascular grafts. At 37℃ in culture, bilayer grafts self-folded into tubular structures. The ionic dissolution products and released heparin from bilayer grafts promoted endothelial cell attachment, expansion and proliferation, thereby achieving rapid endothelialization. The grafts were highly stretchable and had matching mechanical properties with autologous blood vessels.
C-3: Electrochemically Responsive Drug Delivery Systems with Ferrocene-containing Polyelectrolyte Complex Hydrogels for Controlled Release: Victoria Messuri1; Prakriti Dhungana1; Asma Allababdeh1; Cassidy Lyons1; Kyle Duke1; Bhargavi Mummareddy1; Byung-Wook Park1; 1Youngstown State University
Chronic wounds are a major issue that millions of individuals are affected with annually, and the current treatment is costly. This study is to design a smart wound dressing made up of a polyelectrolyte complex hydrogel composed of ferrocene-branched chitosan with alginate to develop a novel drug delivery system. The ferrocene allows for an enhanced drug release kinetics so it can be responsive to the needs of the wound site. The Ninhydrin test, turbidity measurement, gel content, and swelling behavior were performed to characterize the electrochemical responsive hydrogel. The diffusion rates on a phantom skin surface were estimated with drug release kinetics of the model drugs. To design the smart wound dressing, custom-made flexible double layer electrodes containing the PEC hydrogel were fabricated, and then the in-vitro experiment was carried out. The developed wound dressing can be integrated with an enzyme-based biosensing element that detects biomarkers produced by the body.
C-4: Mechanical Evaluation of Polymeric Substrates for Use in Flexible Electronic Applications: Mitchell Melander1; Janet Gbur2; 1Case Western Reserve University; 2U.S. Department of Veterans Affairs
Flexible electronics on thin polymer films have piqued the interest of biomedical researchers due to their ability to more closely match the stiffness of local tissue. Mechanical characterization of these substrates, such as tensile testing, is critical for maximizing the potential of a device. An ASTM standard exists for conducting tensile tests on thin polymer films (ASTM D882), but the shortest approved gauge length for materials of interest is 5 inches. The purpose of this study is to develop a method for conducting tensile tests on thin polymer films with gauge lengths shorter than the recommended 5 inches, as well as determining the best way to prepare smaller specimens to avoid grip slippage. This study has the potential to improve the mechanical characterization of substrates for flexible electronics as well as for all thin polymer films.
C-5: Synthesis and Characterization of Naturally Derived SiO2 and CaO for 45S5 BioactiveGlass for Wound Healing Applications: Samadhan Gaikwad1; Vijay Ingole2; 1Shivaji University Kolhapur; 2Dr. Babasaheb Ambedkar Marathwada University, Aurangabad
The management of skin damage is assumed an unmet clinical need, and no entirely satisfactory solution to this problem exists to date. Using the sol-gel method, we prepare copper (Cu) doped 45S5 BG from naturally derived biomaterials using beach sand as a source of high purity silica and eggshell biowaste as a source of calcium. Using BET, the results of SiO2 and CaO were highly porous, ranging between 189 and 190 nm. The scaffolds are biomimetic mineralized using simulated body fluid that mimics the inorganic composition of human blood plasma, and hydroxyapatite nucleation is confirmed on the scaffold. The highly vascularized chorioallantoic membrane (CAM) that surrounds the embryo can be used to visually inspect the angiogenic effect of therapeutics applied to the ex-ovo chicken embryo. These findings suggested that bioactive glass derived from natural sources could improve biological properties in wound healing applications.