Functional Nanomaterials 2023: Poster Session
Sponsored by: TMS Functional Materials Division, TMS Structural Materials Division, TMS: Nanomaterials Committee, TMS: Composite Materials Committee
Program Organizers: Yong Lin Kong, University of Utah; Sarah Ying Zhong, University of South Florida; Mostafa Bedewy, University of Pittsburgh; Woochul Lee, University of Hawaiʻi at Mānoa; Changhong Cao, McGill University; Kiyo Fujimoto, Idaho National Laboratory; Surojit Gupta, University of North Dakota; Michael Cai Wang, University of South Florida

Monday 5:30 PM
March 20, 2023
Room: Exhibit Hall G
Location: SDCC

Facile Synthesis of Novel Quaternary Zn-Cu-In-S/ZnS QDs- mTHPP Porphyrin Conjugate and Its Photodynamic Therapy of Cancer and Antibacterial Activities: Samuel Oluwafemi¹; ¹University of Johannesburg
    Photodynamic therapy (PDT) is a non-invasive treatment modality that uses photosensitizing drugs (PS) to generate reactive oxygen species for the destruction of abnormally growing cells or microorganisms. Porphyrins are the most widely used PS in PDT however, their clinical application is limited by poor water solubility, which often results in aggregation and their low quantum yield of ROS generation after light absorption in the near infra-red region (NIR. To overcome these limitations and improve PDT efficacy, we herein report the conjugation of Zn-Cu-In-S/ZnS (ZCIS/ZnS) quantum dots (QDs) to 5,10,15,20 meso (4-hydroxyphenyl) porphyrin (mTHPP) and evaluated its PDT efficiency against murine metastatic melanoma (B16 F10 Nex 2) cell line and its antibacterial potency against Escherichia coli (ATCC 25922). The results of this study show that the as-synthesized ZCIS/ZnS – mTHPP conjugate is a suitable and promising class of material for dual anti-cancer and antimicrobial PDT.

Second NIR-absorbing Gelatin Stabilized Gold Nanorods with High Media and Photothermal Stability for Photothermal Cancer Therapy: Thabang Lebepe¹; Samuel Oluwafemi¹; ¹University of Johannesburg
    The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report the synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 ą 2.3 nm and 10 ą 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco’s Modified Eagle’s Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. In vitro, a photothermal therapy study against KM-Luc/GFP demonstrated the gelatin@Au-NRs are effectively destroying the cancer cells.

Study on Aluminum Oxide Thin Film as Etch Stop Layer: Sangwoo Lee¹; Taekjib Choi¹; Jaeyoung Yang²; Joohyun Park²; ¹Sejong University; ²TES Co.,Ltd
    Etch stop layers (ESL) are used in patterning process of the Integrated circuit (IC) fabrication to protect the active layer, which are inter layer dielectrics (ILD) and metal lines, from being damaged during the etching process. The ESL material should have a higher etch selectivity than the active layer. Aluminum oxide compounds (AlOx, AlOC, AlON and AlOCN) are highly suitable for use as ESL due to low dielectric constant (4-9), high etch selectivity, high density (2.5-3.8 g/cm³) and pattern transfer capability. In this work, we focused on lowering the dielectric constant of the amorphous aluminum oxide and increasing the density by controlling the PVD and CVD deposition condition

Synthesis, Characterization and Comparative Study of Polyethylene Oxide / Carbon Nanotubes and Polymethyl Methacrylate Carbon Nanotubes Composites: Sabiha Sultana¹; Noor Saeed¹; Mohib Khan¹; ¹Islamia College Peshawar
    In the present work an attempt was made to synthesize and compare PEO/CNT and PMMA/CNT composites by solvent casting with varying concentration of CNTs while using SDS as a surfactant to enhance dispersion and prevent agglomeration. Different characterization techniques namely Thermal Gravimetric Analysis, Scanning Electron Microscopy, X-ray Diffraction Analysis and Universal Testing Machine were engaged to evaluate and compare PEO/CNT with PMMA/CNT composites. TGA revealed that thermal robustness of PEO/CNT’s boosts sharply by CNT’s whereas PMMA/CNT’s thermal stability increases gradually. SEM images exposed that multiwall CNT’s in PEO accelerates the crystal growth by showing fungus like morphology as witnessed in low magnification images. The low magnification SEM images for PMMA/CNT shows bubble like morphology. The sharp peaks and semi crystalline nature of PEO/CNT’s and Humps and increase in crystallinity with CNT’s for PMMA/CNT’s composites were confirmed by XRD. UTM investigation confirmed that plasticity augments with increasing CNTs loading.