Next Generation Biomaterials: Next Generation Biomaterials III
Sponsored by: ACerS Bioceramics Division
Program Organizers: Roger Narayan, University of North Carolina; Sanjiv Lalwani, Lynntech, Inc.
Tuesday 8:00 AM
October 11, 2022
Room: 318
Location: David L. Lawrence Convention Center
Session Chair: Masanori Kikuchi, National Institute for Materials Science
8:00 AM Invited
Coating of Hydroxyapatite/Collagen Bone-like Nanocomposite by a Modified Electrophoretic Deposition Method and Its Biological Reaction: Masanori Kikuchi1; Tersuo Uchikoshi1; Kaori Iwanami-Kadowaki2; Hanae Arai2; Takeshi Ogasawara2; Masayoshi Uezono2; Keiji Moriyama2; 1National Institute for Materials Science; 2Tokyo Medical and Dental University
Titanium dip-coated with hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) accelerate osseointegration by thrice faster than that to bare Ti and osteoconduction to nano-HAp coated Ti. As lectured in MS&T2020, We successfully prepared high-adhesive strength coating of HAp/Col on Ti by electrophoretic deposition with use of Mg ions. On the other hand, acceleration of osseointegration depends on coating thickness and/or coating amount of HAp/Col. To determine an optimal coating thickness of HAp/Col EPD coating on Ti for quick osseointegration, HAp/Col EPD coated Ti bars at various coating thickness were implanted into sub-periosteum site of rat’s cranium for 4 weeks. The results indicated that HAp/Col EPD-coated Ti at 20-µm thick successfully accelerate osseointegration as the same as the HAp/Col dip-coated Ti. The animal experiments were conducted under the approval number A2020-121C4 of the Animal Ethics Committee of Tokyo Medical & Dental University.
8:20 AM
Comparison of Various Post Coating Treatments on Plasma Sprayed HA Coatings: Jujhar Singh1; Manoj Mittal1; Jujhar Singh2; Gursharan Singh2; Shubham Sharma3; 1Jalandhar-Kapurthala Highway; 2Jalandhar-Kapurthala Highway; 3University Centre for Research and Development and Chandigarh University
Due to very high temperature of plasma in plasma spray coating techniques, some of the properties of HA powder gets deteriorated after spraying to generate coating. It is found from in-vitro studies conducted by many of the researches since it has been used as a coating material for biological applications that as sprayed coating lack some of the requirements which include Crystallization, porosity, surface roughness, refined crystallographic morphology, wide opened cracks. These properties need to be defined with respect to the usage of the implant (location), service life, dissolution/ absorption properties, load bearing capacity and many more. In this study, a comparison of various post coting treatments which includes, post coating heat treatment, stream treatment and cryogenic treatment is done to check the effect of these treatments on the desired properties of HA coating.
8:40 AM Invited
Electrocatalytic Probe for the Disinfection of Dental Pulp: Krista Carlson1; John Colombo1; Jerry Howard1; 1University of Nevada, Reno
Pulpitis results from the attachment of a diverse population of microbes to teeth and dental pulp surfaces, which then form complex, multi-organism biofilms. Currently, the most effective way to remove biofilms is through mechanical disruption as their complex extracellular matrix renders them resistant to pharmacologically-based treatments. However, direct mechanical disruption is challenging because it is difficult to access and remove the biofilm without damaging the in situ dental pulp tissue. We have developed an electrocatalytic titanium dioxide (TiO2)-based probe, which could be used by the general dentist to provide localized delivery of oxidants directly to biofilms. The probe was applied to a mixture of salivary bacteria and stem cells from human exfoliated deciduous teeth (SHEDs). After a 15 s exposure, bacterial cells were destroyed and maximum destruction occurred after 100 s. There was no significant apoptosis or necrosis at any exposure time (up to 300 s) of the SHED cells.