Next Generation Biomaterials: Next Generation Biomaterials I
Sponsored by: ACerS Bioceramics Division
Program Organizers: Roger Narayan, University of North Carolina; Sanjiv Lalwani, Lynntech, Inc.
Monday 8:00 AM
October 10, 2022
Room: 318
Location: David L. Lawrence Convention Center
Session Chair: Roger Narayan, North Carolina State University; Min Wang, University of Hong Kong; Federico Rosei, Énergie Matériaux Télécommunications Research Centre
8:00 AM Invited
3D Printing of Diamond for Biomedical Applications: Kate Fox1; 1RMIT University
Diamond is an interesting biomaterial with history as a coating material for orthopaedic interfaces and heart valves as well as the electrode system for high profile projects such as the Australian Bionic Eye project. As is well established, 3D printing is changing the way that we as biomedical researchers approach patient specific solutions. The challenge however for a material like diamond is the upscale to complex shapes and parts. By combining 3D printing we can achieve this. Here I will discuss the methods we have developed to combine 3D printing and diamond, discussing the new material and reporting on the superior cell/antibacterial interface (compared to titanium alone).
8:30 AM Keynote
Bubbles, Particles, Capsules and Smart Fibers; Their Sustained Manufacturing: Mohan Edirisinghe1; 1University College London
9:00 AM Invited
Materials Development for 3D/4D Printing in Tissue Engineering: Min Wang1; 1University of Hong Kong
3D and 4D printing have proven to be powerful manufacturing platforms for producing high-performance tissue engineering scaffolds for regenerating body tissues. Compared to other fabrication techniques, they have distinctive advantages for constructing complex scaffolds for regenerating complex tissues such as osteochondral tissue and gastrointestinal tissue. Different 3D printing technologies have different requirements for materials/inks to be used, and in many situations these requirements are highly demanding. The requirements for 3D printing materials/inks in tissue engineering include printability, biocompatibility, biodegradation properties, and mechanical properties of printed products. Regarding 4D printing for tissue engineering, the material/ink availability is very limited. We have been investigating 3D/4D printing in tissue engineering and employing/developing 3D printing technologies such as selective laser sintering, cryogenic or low temperature extrusion 3D printing, and digital light processing. This talk will share our experience in developing new materials, particularly composites and hybrids, for 3D/4D printing of advanced tissue engineering scaffolds.
9:30 AM Invited
Novel Chevrel Phase Nanomaterials: Pelagia Gouma1; 1The Ohio State University
The Chevrel Phases belong to a unique and versatile family of materials with diverse crystal structures and outstanding properties. Chevrel Phases are proposed here as the next generation of multifunctional materials. These compounds are ternary Mo chalcogenides with a chemical formula MxMo6X8 [where x = 0-4; X = chalcogen (S, Se, Te) but can be partially substituted by halogens elements, and even oxygen; and Mo may be partially or totally replaced by another transition metal (e.g. W, Nb, Ta, Re)]. These compounds are amenable to crystallographic control of their electronic structure and physical properties. The emphasis of this talk is on Chevrel Phase synthesis using advanced and sustainable combustion processes (such as self-propagating high temperature synthesis) and/or combined with non-mechanical drawing processes (such as high-throughput electrospinning) to synthesize these ternary chalcogenides. Examples of potential applications of these materials are given here too.
9:50 AM Break
10:10 AM Cancelled
Structure / Property Relationships in Biomaterials at the Nanoscale: Federico Rosei1; 1INRS Centre for Energy, Materials and Telecommunications
Nanostructuring materials allows to optimize their properties, by exploiting size effects. We created nanopatterns that act as surface cues, affecting cell behavior. Chemical oxidation creates nanoscale topographies, that improve biocompatibility. Our treatment provides a differential signal, inhibiting fibroblast proliferation while promoting osteoblast growth in vitro. Related strategies for tissue regeneration and repair are also discussed [1-4]. Improving antibacterial properties using laser/plasma strategies and growing graphene oxide coatings will be discussed [5-7]. Finally, sensing and therapeutic approaches can be harnessed by exploiting the optical properties of nanocrystals, including Quantum Dots and upconverting nanoparticles [8-13]. [1] Nanolett 9,659(2009) [2] Adv.Mater. 20,1488(2008) [3] Tissue and Cell 58,33(2019) [4] ACS Biomaterials Sci. & Eng. 6,1165(2020) [5] Diam.Rel.Mater. 48,65(2014) [6] Nanoscale 6,8664(2014) [7] Trends Biotechnol 33,637(2015) [8] Nanoscale 7,5178(2015) [9] Small 11,5741(2015) [10] J.Phys.Chem.B 120,4992(2016) [11] Nanoscale 10,791(2018) [12] Chem Mater 31,5160(2019) [13] Chem.Sci. 11,6653(2020)
10:30 AM Invited
Tunable Nano-cerium Oxide for Radiation Mitigation: Sudipta Seal1; Melanie Coathup1; Craig Neal1; Fei Wei1; 1University of Central Florida
Engineered cerium oxide nanoparticles (CNPs) having mixed valences (Ce3+ and Ce4+) on their surface are known to scavenge excess reactive oxygen species (ROS), due to their redox active nature. We have shown that the injection of CNPs into a murine model exposed to ionizing radiation could lead to cytoprotection in tissues. Instances of DNA-double strand breaks as well as ROS concentration in tissue samples were also found to be significantly lower for specimens treated with CNPs. Our ongoing studies will present the role of CNP as radiosensitizer in tumor therapy. Another example will include in orthopedics application where increased bone loss and risk of fracture are the main challenges for cancer patients under ionizing radiation therapy. We have further investigated the effect of CNPs in reducing IR-induced functional damage in human bone marrow-derived mesenchymal stromal cells, further complemented by studying ROS levels, cellular proliferation, morphology, senescence, DNA damage, etc.
10:50 AM
Digital Light Processing-based Additive Manufacturing of Medical Devices: R Sachan1; Roger Narayan1; 1NC State University
Polytetrafluoroethylene is finding growing use in many types of medical devices due to its heat resistance and bioinertness. Processing of polytetrafluoroethylene into medical devices is complicated by the fact that it exhibits a glass transition temperature of 185 degrees Celsius. This presentation will consider the processing of arrays of solid microneedles(https://doi.org/10.1557/s43579-021-00121-0) and hollow needles (https://doi.org/10.1007/s11837-021-04978-3) made of polytetrafluoroethylene by digital light processing (DLP)-based additive manufacturing. Confocal laser scanning microscopy was used to assess the dimensions of the medical devices. Raman spectroscopy and X-ray photoelectron spectroscopy were used to evaluate the chemical bonding and composition of the medical devices, respectively. Nanoindentation was used to understand the hardness and stiffness of the printed polytetrafluoroethylene. In vitro studies were used to evaluate the functionality of the solid microneedles and hollow needles. Our results suggest that DLP-based additive manufacturing is useful for processing polytetrafluoroethylene into functional skin-contacting medical devices.