3D Printing of Biomaterials and Devices: Session II
Sponsored by: ACerS Bioceramic Division
Program Organizers: Sahar Vahabzadeh, Northern Illinois University; Susmita Bose, Washington State University; Amit Bandyopadhyay, Washington State University; Mukesh Kumar, LincoTek Medical; Mangal Roy, Indian Institute of Technology - Kharagpur (IIT-Kgp)
Monday 2:00 PM
October 10, 2022
Room: 319
Location: David L. Lawrence Convention Center
Session Chair: Candan Tamerler, University of Kansas; Syam Nukavarapu, University of Connecticut
2:00 PM Invited
3D Printing of Nanomaterials-based Biomedical Electronics: Yong Lin Kong1; 1University of Utah
The integration of nanomaterials with 3D printing can create biomedical devices with an unprecedented level of functional integration. My research focuses on the multiscale integration of nanomaterials in an extrusion-based 3D printing process, enabling the creation of bioelectronics that can address unmet clinical needs. As an example, I will first highlight the development of the 3D printing of active electronics, which extended the reach of 3D printing. In the second part of the talk, I will highlight the development of a 3D printed gastric resident electronics system, which leverages the significant space and immune-tolerant environment available within the gastrointestinal tract to circumvent the potential complications associated with surgically placed medical implants; and explore the possibility of integrating reinforcement learning algorithm to adapt to environmental changes. Ultimately, we strive to address unmet clinical needs by creating 3D printed biomedical electronics that can better interface with a broad range of three-dimensional systems.
2:30 PM Invited
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering: Syam Nukavarapu1; Aleksandra Golebiowska1; 1University of Connecticut
Osteochondral (OC) defect repair remains a significant clinical challenge due to the complexity of the OC unit. Traditional fabrication methods are often met with limitations in replicating the unique structure of the OC tissue. Three-dimensional (3D) printing allows for development of precise microstructural architecture. In this study, a series of zonal-structured scaffolds were fabricated via 3D printing with controlled porosity to support each layer of the OC unit along with a graded scaffold intended to enable the formation of the OC interface. Scaffolds demonstrated controlled hierarchical structure within each region and structural variation along the length with structural integrity and mechanical properties within the range of trabecular bone. Scaffolds were also developed with regional compositional organization through co-deposition of polymeric framework and a cell-laden hydrogel demonstrating selective homogenous distribution of the required cell population. This work developed controlled and reproducible multi-regional and gradient scaffolds for complex tissue engineering applications.
3:00 PM
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates: Swantje Simon1; Maximilian Meyse1; Tobias Fey1; 1Friedrich-Alexander-Universität Erlangen-Nürnberg Institute of Glass and Ceramics
The replica technique is one of the most established manufacturing methods of highly porous scaffolds for bone tissue engineering. Despite a multitude of possible templates, this method is limited in terms of reproducibility and periodicity. We overcome this issue by 3D-printing of designed periodic polymer templates which we further process with the replica technique to obtain cellular ceramics with adjustable micro- and macrostructure. The periodic structure (Kelvin cells) was created using a computer-aided design (CAD) software changing the strut shape and thickness. The structures were 3D-printed with rigid polymer and afterwards processed with the classical replica technique. The combination of polymer 3D-printing and the replica technique brings us one-step closer to the excellent replication of cellular materials.
3:20 PM Break
3:40 PM Invited
Laser-Based 3D Printing for Medical Applications: Roger Narayan1; 1University of North Carolina
Laser-based 3d printing methods such as two photon polymerization, laser micromachining, and laser direct writing have been used to create surfaces with small-scale features for many types of medical applications. Several types of medical devices, such as scaffolds for tissue engineering and microfluidic devices, have been processed using two photon polymerization. For example, we used two photon polymerization to manufacture small-scale lancet-shaped biomicrofluidic devices known as microneedles; these devices have potential use for transdermal delivery of pharmacologic agents or transdermal sampling of body fluids. Methods to optimize the processing parameters and postprocessing procedures for medical applications will be described. For example, the selection of biologically-appropriate photoinitiators for use in medical applications will be discussed. The biological and functional evaluation of two photon polymerization-created devices will be considered. Appropriate steps in the development of two photon polymerization as a commercially scalable manufacturing method will be described.
4:10 PM Cancelled
Ultrasound-assisted Bioprinting using Composite Bioinks for Soft Tissue Engineering: Rohan Shirwaiker1; Parth Chansoria2; 1North Carolina State University; 2ETH Zurich
For engineering biomimetic soft tissue constructs, it is essential to impart appropriate three-dimensional (3D) organization to cells and extracellular constituents during biofabrication as a precursor to achieving tissue-specific biological and biomechanical functionality. This talk will highlight a new, versatile ultrasound-assisted bioprinting (UAB) approach that uses acoustic radiation forces generated via superimposition of bulk acoustic waves to pattern cells and structural cues in 3D hydrogel constructs. The application of UAB to create cartilaginous tissue constructs featuring bulk anisotropy using gelatin methacryloyl (GelMA)-based composite bioinks comprising stem cells and cell adhesion-promoting additives (polycaprolactone micro-fibers, collagen microaggregates) will be discussed. The hybridization of UAB with stereolithography and extrusion printing to create patterned constructs with perfusable channels, which is critical for engineering biomimetic vascular organs, will be also demonstrated.