Next Generation Biomaterials: On-Demand Poster Presentations
Sponsored by: ACerS Bioceramics Division, TMS Biomaterials Committee
Program Organizers: Roger Narayan, University of North Carolina; Min Wang, University of Hong Kong; Shawn Allan, Lithoz America LLC
Friday 8:00 AM
October 22, 2021
Room: On-Demand Poster Hall
Location: MS&T On Demand
Poster
4D Printed Shape Morphing PDLLA-co-TMC/GelMA Scaffolds for Tissue Regeneration: Xiaodie Chen1; Jiahui Lai1; Min Wang1; 1University of Hong Kong
4D printed tissue engineering scaffolds with shape morphing ability are very useful for the regeneration of many body tissues. Currently, shape memory polymers are commonly used materials for 4D printing in tissue engineering. But these materials are mostly synthetic polymers that do not provide good substrates for cell spreading and adhesion. Combining a synthetic shape memory polymer with a natural hydrogel (with excellent biocompatibility) is an effective way to obtain a polymeric material with both desired shape memory ability and good biocompatibility for 4D printing. In this study, shape morphing scaffolds with good biocompatibility were fabricated via 4D printing of polymer blends, which were composed of shape memory PDLLA-co-TMC and natural hydrogel GelMA (at 1:1, 2:1 and 3:1 blend ratios). The addition of GelMA in PDLLA-co-TMC improved the printability, stretchability and biocompatibility of the material while shape morphing ability was maintained. The blend ratio was found to affect these properties.
Metal Release from a Biomedical CoCrMo Alloy in Mixed Protein Solutions under Static and Sliding Conditions – Effects of Protein Aggregation and Metal Precipitation: Zheng Wei1; Valentin Romanovski2; Luimar Filho3; Cecilia Cecilia3; Yolanda Hedberg1; 1Western University; 2National Academy of Sciences of Belarus; 3Uppsala University
Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical, chemical, and electrochemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from a CoCrMo alloy was investigated in physiologically relevant solutions containing albumin and fibrinogen at physiological pH in static and sliding conditions for time periods between 1 and 24 hours. Proteins induced significant precipitation of metals and protein aggregates, which resulted in strongly underestimated released amounts of Co and Cr, but not Mo, especially under sliding conditions. Protein aggregates were found to precipitate on the surface of CoCrMo under static conditions.