BioNano Interfaces and Engineering Applications: Bionano Interfaces & Engineering Applications IV and V
Sponsored by: TMS Functional Materials Division, TMS Structural Materials Division, TMS: Biomaterials Committee
Program Organizers: Candan Tamerler, University of Kansas; Hendrik Heinz, University of Colorado Boulder; Kalpana Katti, North Dakota State University; Terry Lowe, Colorado School of Mines; Po-Yu Chen, National Tsing Hua University

Wednesday 2:00 PM
March 2, 2022
Room: 201A
Location: Anaheim Convention Center

2:00 PM  Keynote
Bioinspired Wear-resistant Triboelectric Nanodevice for Biomechanical Energy Harvesting: Ming-Zheng Huang1; An-Rong Chen1; Naveen Tiwari1; Yung-Hsin Chen1; Zong-Hong Lin1; 1National Tsing Hua University
    Bionic materials having the inclusive functions and properties present in the nature are of great importance in the development of human-machine interfaces. Triboelectric nanogenerator (TENG) is a novel and sustainable technology for energy harvesting, among which the sliding mode TENG are considered as the high conversion efficiency mode. However, extreme friction wear limits the output stability and reliability, reducing the use of sliding mode TENG for mechanical energy harvesting. Here, we report a bionic composite film, which is inspired by the structure and the composition of snake scales as the friction layer for TENG to overcome the problem. Through in-depth experimental analysis of structural and compositional characteristics, we demonstrated that bionic composite film has greater charge transfer, wear resistance and can maintain a stable output even under high-speed sliding operation. This study highlights the merits in achieving higher interface stability and promotes the great potential of TENG for easy commercialization.

2:40 PM  Invited
Reverse Engineering Spider Silk by Disassembly and Assembly: Dinidu Perera1; Linxuan Li1; Qijue Wang1; Hannes Schniepp1; 1William & Mary
    Spider silk combines outstanding strength and toughness with biocompatibility and light weight, thus outperforming some of the best synthetic materials. Despite extensive research, comprehensive experimental evidence of the formation and morphology of the internal structure of spider silk is still limited and controversially discussed. We used mechanical exfoliation to completely exfoliate spider silk for the first time. This showed that the silk of the golden orb-weaver is entirely composed of parallel, 10 nm-diameter nanofibrils featuring a particular morphology. Furthermore, we show that the silk protein possesses an intrinsic mechanism to form nanofibrils of the same morphology via shear-induced self-assembly, which can be easily triggered in vitro. This knowledge will help understand the fundamentals of this exceptional material, paving the way for the realization of silk-based high-performance materials.

3:10 PM  
Peptide-mediated Remineralizable Collagen Fibrils as a Model for Dentin Repair: Nilan Kamathewatta1; Quang Ye1; Paulette Spencer1; Candan Tamerler1; 1The University of Kansas
    Collagen forms the major insoluble fibrous protein in most tissues. Type I collagen is the predominant organic component in dentin. Cariogenic bacteria demineralize and decompose dentin. Current treatment generally involves removal of caries-infected, but retention of caries-affected dentin. To date, the methods to repair damaged dentin have not consistently remineralized dentin. We used type I collagen as a model system to investigate peptide-mediated remineralization on self assembled collagen network. The morphologic and chemical changes in the collagen network in the presence and absence of hydroxyapatite-binding peptide were studied as a function of time following alkaline phosphatase exposure using AFM, micro-Raman spectroscopy, and SEM-EDX. With increased reaction time, the mineral particles form clusters, the phosphate band is better resolved, and carbonate content is decreased. These results indicate a higher degree of crystallinity and the results support physiological re-mineralizable collagen fibrils as a target for the repair of deficient dentin.

3:30 PM  
Controlled Synthesis of Polystyrene/Citrate Capped AuNPs Microparticles for the Colorimetric Detection of Hg2+ Ions through Aptamer-target Interaction: Ana Ulloa1; Min Zhao2; Qiyue Liang2; George Chiu3; Jan Allebach2; Lia Stanciu1; 1Purdue University-Materials Engineering; 2Purdue University- ECE; 3Purdue University
    Heavy metals toxicity has been proven to be a major public health concern. Among the heavy metals, mercury is considered the most toxic, but unfortunately, it is still widely distributed in the environment. Current detection methods for its monitoring include ICP-MS, HPLC, and ICL-AES and despite their high sensitivity and selectivity, they are still complex, required trained personnel, and are not suitable for On-Site detection. Therefore, the development of user-friendly and reliable sensors is necessary. This work puts forward a controlled synthesis process of aptamer-labeling Ps-AuNPs microparticles for the sensitive and quantifiable detection of Hg2+ ions (LOD= 1ppm) through colorimetric assays. The resulting paper-based microfluidic device (-PAD) as manufactured consists of a cost-effective, portable, and versatile aptasensor that serves as a basis for the fabrication of universal paper-based colorimetric platforms with the capability of multiplex and multi-replicates and it is promising for On-site applications in agriculture and environmental safety.