Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry: Poster Session
Program Organizers: Navin Manjooran, Solve; Gary Pickrell, Virginia Tech
Monday 5:00 PM
October 10, 2022
Room: Ballroom BC
Location: David L. Lawrence Convention Center
Session Chair: Gary Pickrell, Virginia Tech; Navin Manjooran, Chairman, Solve
H-13: Impedimetric Determination of Cortisol Using Gold Nanoparticles Functionalized Laser Induced Graphene Electrode: Kyle Duke1; Jose Gonzalez-Garcia1; Jennah Markovitch1; Kyle Preusser1; Victoria Messuri1; Anthony Romeo1; Bhargavi Mummareddy1; Pedro Cortes1; Byung-Wook Park1; 1YSU
Wearable biosensors have received a lot of attention for their promising applications in personalized medicine. Cortisol is a biomarker for various diseases and plays an important role in metabolism, blood pressure regulation, and glucose levels. This study is to create a flexible, wearable biosensor to detect cortisol in bodily fluid through contact with the skin. A direct laser writing technique was used to produce laser-induced graphene (LIG). The LIG was modified with gold nanoparticles to enhance impedance response. For non-invasive extraction of biomarkers, a hydrogel layer was incorporated onto the electrode surface. A cortisol antibody was immobilized through the surface chemistry. Cyclic voltammetry and electrochemical impedance spectroscopy were used to characterize the electrode and perform detection of cortisol. The characterizations were carried out in terms of detection limit, selectivity, sensitivity, and response time. Using 3D printed wristbands and wireless communication devices, it may be possible to monitor personnel in real-time.
H-14: Multi-Element Surface Acoustic Wave (SAW) Sensors for Methane Detection: Daejin Kim1; Jeffrey Culp1; Jagannath Devkota1; Ruishu Wright2; 1National Energy Technology Laboratory/NETL Support Contractor; 2National Energy Technology Laboratory
America relies on natural gas as a major energy source (approximately 40% in 2021). However, an estimated 2.3% of the gross natural gas production escapes from U.S. gas pipelines annually, resulting in a loss of ~$2 billion a year. The leaked methane gas is a powerful greenhouse gas which is 25 times more potent than CO2. Therefore, it is critical to detect leaks from natural gas pipelines using a sensitive methane sensor to alleviate the impact of methane emissions on both economy and environment. In light of this fact, we have developed a multi-element SAW array sensor which is coated with various sorbent materials to demonstrate methane sensing under environmental conditions. The effects of sorbent particle size and binding agents on the sensing performance will be discussed in both dry and humid conditions. The comparison between the wired and wireless detection modes of the SAW sensors will also be presented.
H-15: Transition Metal Doped Cerium Oxide Nanozymes: Physical and Biological Characterizations for Interactions with Oxidative Stress: Samantha Stoltz1; Sudipta Seal1; Elayaraja Kolanthai1; Craig Neal1; Yifei Fu1; 1UCF AMPAC Lab
Cerium oxide nanoparticles (CNPs) modulate cytotoxic reactive oxygen/nitrogen species concentrations via Ce3+/Ce4+ inter-conversion, with equilibrium Ce3+-states, and related oxygen vacancy concentrations, influencing particle redox-reaction characters. We hypothesize that Zn/ Cu incorporation (5, 10, and 20 mol%) should influence surface vacancy density, as well as provide additional reaction sites with unique surface chemistry, and potentially lead to formation of NPs with broad therapeutic activity. Electron microscopy of all samples showed ~5 nm spherical particles, while X-ray diffraction and photoelectron spectroscopy and detailed Zn/Cu phase character. SOD-mimetic radical scavenging was limited across samples (ascribed to low [Ce3+], though increased slightly with increasing Zn/Cu. Interestingly, CAT-mimetic activity varied inversely with Zn-fraction, contrasting SOD trends. Further, Cu introduction showed negligible effect on CAT up to 20 mol%, whereupon activity increased substantially. In vitro studies (MTT, live/dead assays) confirmed Zn/Cu incorporation into biocompatible CNPs imparted cytotoxic character toward a breast cancer cell line (MCF-7).