|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||PCL-Gelatin Nanofibers for Extended Drug Release
||Tyler Nelson, Hrishikesh Munj, Carol Lee, Heather Powell, David Tomasko, John Lannutti
|On-Site Speaker (Planned)
Electrospun polymer fibers exhibit a microstructure and morphology that closely mimics native extracellular matrix providing a useful tool for tissue engineering applications. Supercritical CO2 processing allows for the incorporation of local, sustainable drug delivery to electrospun fibers without altering microstructure. Previous attempts to use CO2 impregnation of electrospun polycaprolactone fibers at liquid, supercritical conditions resulted in melting. 50:50 blended PCL:gelatin electrospun fibers with or without crosslinking were impregnated with a test compound, carboxytetramethylrhodamine, using CO2 at either subcritical or supercritical conditions for 30 min. Subsequent release profiles in phosphate buffered saline at 37°C were obtained over a 25 day period. DSC, FTIR-ATR, and XRD were utilized to characterize the effects of gelatin on PCL. In the presence of gelatin, the blend scaffold was able to maintain its microstructure under liquid- and supercritical-CO2 infusion conditions. Optimizing the crosslinking, and infusion conditions resulted in finer control of release.