A refractory U-Mo associated ore containing jordisite enclosing U, Mo component, and impeding penetration, diffusion process of leaching, oxidation agent is investigated through three approaches of focusing on U, Mo extraction. The results indicate flotation beneficiation without followed metallurgical process is not appropriate because of high target metals loss rate via water leaching. H2SO4, H2O2 dosage recommended to oxidative leaching are 10% and 6～8% of ore mass, and U, Mo leaching rate are 92.71% and 52.16% respectively. For the acid pressure leaching, U, Mo leaching rate 92.34% and 68.38% are achieved under optimal temperature 130～140oC and H2O2 dosage 8% combined with pressure air 0.6 MPa. Under fluidized bed furnace roasting parameters include air flow rate 0.64m/s, air ore ratio 0.3m3/kg at roasting temperature 550oC and time 30 sec with U, Mo leaching rate 93.2% and 89.5%, so enhanced metallurgical process effectively destroy wrapper and increase metal recovery rate.