| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Exploring Single Electrospun PLGA Fiber Mechanics and Fiber Mat Applications in Cardiac Bioengineering |
| Author(s) |
Lihua Lou, Tanaji Paul, Alberto Sesena Rubfiaro, Jin He, Arvind Agarwal |
| On-Site Speaker (Planned) |
Lihua Lou |
| Abstract Scope |
The application of flexible submicron fibers as biomedical scaffolds depends on their biocompatible/biodegradable features and critical mechanical roles in maintaining bio- homeostasis and functions. Although attempts to measure single fiber mechanics have been made, an approach to observe and understand adhesion behavior in real-time while subjected to mechanical loading is poorly understood. Using a high-resolution camera, we developed an in-situ technique to measure and observe fiber adhesion behavior in dry and wet conditions to mimic bio- environments. We hypothesized the correlation between the mechanical properties of fiber and cell/soft biological tissues. Additionally, the applications of aligned or random-distributed fiber mat in cardiac bioengineering are investigated. We comprehensively analyzed the influences of fiber distribution on cardiomyocyte synchronization and beating mechanics. We precisely examined a bio-friendly material’s mechanical properties and disclosed its profound and striking roles in cardiac bioengineering. |