|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||In-Vitro and In-Vivo Osteocompatibility Assessment for Carbon Nanotube Reinforced Hydroxyapatite Coatings
||Debrupa Lahiri, Ana Paula Benaduce, Sybille Facca, Lidia Kos, Nadia Benkirane-Jessel, Arvind Agarwal
|On-Site Speaker (Planned)
Carbon nanotubes (CNT) assure promises as reinforcement to hydroxyapatite (HA) by impressive improvement in its eternal problem-areas related to low fracture toughness and wear resistance. But presence of CNT in HA provokes a debate about its biocompatibility. Our studies, in recent past, have dealt with in-vitro and in-vivo evaluation of osteocompatibility and osseointegration for plasma sprayed HA-CNT coatings. In-vitro viability, proliferation-kinetics and gene-expression studies do not indicate any cytotoxic effect of CNT on osteoblasts. CNT containing wear debris is found non-cytotoxic to macrophages and osteoblasts. Osteoblast shows higher adhesion strength on HA surface in presence of CNT. In-vivo study of HA-CNT coated Ti-6Al-4V implants, using rat model, has shown no sign of cytotoxicity and better osseointegration than on HA. HA-CNT coating and neobone near it show higher elastic modulus than on HA upon in-vivo exposure. In short, the presence of CNT is found positively influencing the osteocompatibility of HA.