|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Bio Nano Interfaces and Engineering Applications
||Rules of Induction Towards Chimeric Antimicrobial Peptide Design as Implant Biocoatings
||Kyle Boone, Sarah VanOosten, Marcos Barbosa Simoes, Candan Tamerler
|On-Site Speaker (Planned)
Designing new peptides with predictable ability for a specific material function is a current challenge in biomimetic enabled material systems. Explicit structure-function relationships are in progress to overcome this challenge because the effectiveness of candidate peptides is not obvious without experimental determination of the function level. This becomes even more complex in designing chimeric peptides that may possess two or more functions. Here we apply this approach to design implant specific antimicrobial peptides to engineer as a bio-self-assembled molecular tools. We incorporate variety of spacers that provides predictable structures to keep chimeric activity in our design. With our experimental evaluations, we validate the rules we generate in designing the peptides. We will demonstrate a unique rule found where a peptide that consistently forms a 13-aa-alpha helix would be highly effective against one pathogen, but it would not be highly effective against another one, e.g. S. Mutants and E. coli.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)