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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Bio Nano Interfaces and Engineering Applications
Presentation Title Rules of Induction Towards Chimeric Antimicrobial Peptide Design as Implant Biocoatings
Author(s) Kyle Boone, Sarah VanOosten, Marcos Barbosa Simoes, Candan Tamerler
On-Site Speaker (Planned) Kyle Boone
Abstract Scope Designing new peptides with predictable ability for a specific material function is a current challenge in biomimetic enabled material systems. Explicit structure-function relationships are in progress to overcome this challenge because the effectiveness of candidate peptides is not obvious without experimental determination of the function level. This becomes even more complex in designing chimeric peptides that may possess two or more functions. Here we apply this approach to design implant specific antimicrobial peptides to engineer as a bio-self-assembled molecular tools. We incorporate variety of spacers that provides predictable structures to keep chimeric activity in our design. With our experimental evaluations, we validate the rules we generate in designing the peptides. We will demonstrate a unique rule found where a peptide that consistently forms a 13-aa-alpha helix would be highly effective against one pathogen, but it would not be highly effective against another one, e.g. S. Mutants and E. coli.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

An Electrochemical Approach to Control Surface Behavior of Peptides Self-assembling on Graphite
Analytical Study on the Effect of Interface Properties in Brick and Mortar Structured Composites
Bacterial Surface Display for Discovery and Study of Peptide-Directed Material Interfaces
Biological Fabrication of Nanodevices by Protein Supramolecules
Coarse-Grained Modeling of Interaction between Vesicle and Active Rotational Nanotube
Computational Models of Peptide-Surface Interactions Drawn from Bacterial Display Studies: Up Close and Personal
Computational Strategies for Amyoloidogenic Proteins Interacting with Gold NPs
D-1: Elucidation of Sequence-Dependent Structure/Function Relationships for Bimetallic CoPt Nanoparticles
D-2: High Affinity Surface Attachment of F1 Rotary Motors for Nanodevice Fabrication
D-3: Selection of Peptide Aptamer with Ultrahigh Affinity for TiO2 by Combination of Phage Display and Electroporation
D-4: Self-healing in Super-tough Double Network Hydrogels
Design Rules for Molecularly Interfacing Biology and Engineered Solids towards Biomimetic Devices
Designer Self-assembling Peptides for Programming the Bio-material Interface
Effect of Water on the Mechanical Properties of Lignin Carbohydrate Complex
Engineered Interfaces for Dehydrogenase Based Self-Integrated Electrode System
Engineering of Bio-Nano Interfaces on 2D Nanomaterials by Self-Assembled Peptides
Engineering of Biodegradable Boron-Based, Carbon Enriched Nano Fiber in A Hybrid Composite Via DIMOX, Rheocasting and Thixocasting
Gene Expression Profiling of Preosteoblasts on Conventional and Nanostructured Bulk Titanium
Graphene Oxide Reinforced Double Network Hydrogel
Graphite Oxide/Cellulose Composites as Innovative Solid Support Material for DNA Extraction Applications
How Do Nano and Microscale Surface Topographies Affect Bacterial Attachment? Designing a New Generation of Antimicrobial Surfaces
Implantable Magnetic Nanocompsites for Cancer Treatment
Interrogating Bio-Nano Interactions and Enhancing Materials Properties
Mechanism of Specific Recognition of Pt Nanocrystals by Peptides and of their Formation from Seed Crystals
Modeling the Organic-Inorganic Nano Interface in Nanocomposites in Bone Tissue Engineering
Molecular-level Understanding of Peptide Adsorption at Fluid/Solid Interfaces through Molecular Simulation and Its Exploitation in Practise
Nonuniform Breaking of Molecular Bonds, Peripheral Morphology, and Releasable Adhesion by Elastic Anisotropy in Bio-adhesive Contacts
Novel Gyratory Methods for Forming Smart Biointerfaces
Precision Assembly of Biologically Functional Abiotic/Biotic Materials
Recluse Spider's Silk Nanoribbons — a Quasi-2D Protein Material with Outstanding Mechanical and Adhesive Properties
Rules of Induction Towards Chimeric Antimicrobial Peptide Design as Implant Biocoatings
Self-reinforced Fibro-porous 3D Tubes for Vascular Graft Applications
Stimuli Responsive and Reconfigurable Nanoparticle Biointerfaces
Synthesis of Self-cleaning, Transparent and Superhydrophobic/Oleophobic Metal Oxide Coatings by Atmospheric Pressure Plasma Technique
The Structure and Mechanics of the Interfaces within Biological and Bio-inspired Materials
Thermodynamic Characterization of Self-Assembled Peptides on Graphite

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