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Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Biodegradable Materials for Medical Applications
Presentation Title Long Term Biocompatibility of Zinc and its Alloys for Absorbable Vascular Scaffolds
Author(s) Roger Guillory, Jaroslaw Drelich, Jeremy Goldman
On-Site Speaker (Planned) Roger Guillory
Abstract Scope The search continues for a biodegradable metal that can serve as temporary vascular scaffolding. Since introducing zinc as a candidate stent material with ideal degradation rates (2013), we have successfully pursued alloying paths to increase the mechanical strength. Here, we report on the long term arterial biocompatibility of select alloys, relative to pure zinc. Rat arteries with Zn, Zn-Li, and Zn-Mg wire implants were collected at 6 and 12 months and examined histologically for inflammation and (SMC) distribution. The alloying additions increased general inflammation and arterial injury relative to pure zinc. All arteries were patent at 12 months, with minimal progression of negative biological responses. Neointimal tissue growth was similar on pure zinc and 316L stainless steel wires at 3 and 6 months. The work demonstrates the feasibility of alloying to improve Zn’s mechanical strength while retaining biocompatibility.
Proceedings Inclusion? Planned: Supplemental Proceedings volume

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Biocompatibility of Biodegradable Mg-Zn-Ca Metallic Glass
Biodegradable Borate Glass for Wound Healing and Bone Regeneration Implants via Boronizing
Biodegradable Mg-implants – Current Market Experiences
Biological Response of Surface Modified Mg-Sr Alloy for Orthopedic Applications
Comparative Study on Corrosion Behavior WE33 in Immersion and Polarization Influenced by Heat Treatment
Corrosion Properties of Mg-Ca-Gd Alloy Applied to Biodegradable Implants
Designing Polymeric Membranes for Medical Applications
Development of a Bioresorbable Vascular Scaffold for Treating Coronary Artery Disease: A Case Study
Development of a New Biodegradable Surgical Clip Made of a Magnesium Alloy: Evaluation of its Safety and Tolerability for Canine Cholecystectomy
Development of Biodegradable Operative Zinc Clips for Ligation
Development of Porous and Biodegradable Hydroxyapatite/Mg Alloy Composite as Biodegradable Implants for Orthopaedic Applications
Effect of Additive Zinc on Mechanical Properties and Degradation Behavior of Magnesium
Fe-based Alloys: A New Class of High Strength Low-degradation Biodegradable Metals for Health Applications
Fundamentals of the Theory of Biodegradable Metals—Definition, Biodegradability and Biosafety Criteria and its Guidance on Material Design
Influence of Casting on Microstructure and Corrosion of Mg-Ca-Zn Alloys for Biomedical Application
Is Corrosion Fatique Relevant for Biodegradable Magnesium Implants?
Long Term Biocompatibility of Zinc and its Alloys for Absorbable Vascular Scaffolds
Mechanical and Corrosion Property Profile of Biodegradable, Open-porous Scaffolds Made of Sintered Magnesium Short Fibers
Mechanical Properties of Nanocrystalline Bioresorbable Fe-Mn Alloy
Metal Injection Molding (MIM) of Mg-alloys for Biomedical Applications
Microstructural Evolution and Mechanical Properties of Zn-Ti alloys for Biodegradable Stent Applications
Microstructure and Mechanical Properties of Mg-Gd Alloys as Biodegradable Implant Materials
Microstructure Properties and In-vitro Degradation Behavior of the Bioresorbable Magnesium Alloy ZNdK100
Opportunities Offered by Zinc Alloys for Degradable Implants: Recent Trends and Developments
Osteosynthesis in a Growing Ovine Model using Bioresorbable Rare-earth-free Magnesium Screws
Osteosynthesis in an Osteoporotic Rat Model Using Magnesium-based Pins
Progress in Absorbable Wire Technology for Next Generation Devices
Resoloy – the Resorbable Mg Alloy for Stents
Study of Biodegradable Zn-Cu-based Alloys for Cardiovascular Stents Applications
Study on Polylactide-coconut Fibre for Biomedical Applications
Surface Modification of Biomaterials by Plasma-based Technology
The Preparation of a Mg-Zn-Nd Alloy Wire and its Potential Application in Medicine
Visualisation of Implant Failure by Synchrotron Tomography
Where Do We Stand on Development of Ideal Biodegradable Zinc Material for Vascular Stenting?

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