|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||H-3: Long Term Biocompatibility of Zinc and its Alloys for Absorbable Vascular Scaffolds
||Roger Guillory, Jaroslaw Drelich, Jeremy Goldman
|On-Site Speaker (Planned)
The search continues for a biodegradable metal that can serve as temporary vascular scaffolding. Since introducing zinc as a candidate stent material with ideal degradation rates (2013), we have successfully pursued alloying paths to increase the mechanical strength. Here, we report on the long term arterial biocompatibility of select alloys, relative to pure zinc. Rat arteries with Zn, Zn-Li, and Zn-Mg wire implants were collected at 6 and 12 months and examined histologically for inflammation and (SMC) distribution. The alloying additions increased general inflammation and arterial injury relative to pure zinc. All arteries were patent at 12 months, with minimal progression of negative biological responses. Neointimal tissue growth was similar on pure zinc and 316L stainless steel wires at 3 and 6 months. The work demonstrates the feasibility of alloying to improve Zn’s mechanical strength while retaining biocompatibility.
||Planned: Supplemental Proceedings volume