Every single day, medical grade wire is used to save and mend thousands of lives worldwide, in devices ranging from bone cerclage cables to cerebral vascular aneurysm occluders. Typically, such devices are designed to be stable in the in vivo environment, with appropriate mechanical properties for the intended application. What if we could achieve dramatically better long-term outcomes through materials that remodel in complement to local tissue healing? Such is the promise of absorbable metals. Critically, properties that evolve with time complicate implant design, and the engineering experiments and resultant data needed to inform responsible design are demanding. Still, the value proposition is high, and the reward in better pediatric devices alone renders our efforts worthwhile. In this talk we explore research extending from 2009 to present in absorbable metallic wire, exploring the interplay between device application, materials selection, and processing. Target application areas include wire-based orthopedic and vascular devices.