|About this Abstract
||Materials Science & Technology 2011
||MS&T'11 Poster Session
||026 Synthesis and UV-Enhanced Cytotoxicity of Pure and Ni-Doped ZnS@ZnSe Quantum Dots
||Melissa Cruz, Sonia Bailon
|On-Site Speaker (Planned)
Photodynamic therapy (PDT) in presence of semiconductor quantum dots (QDs) is a promising technique for cancer treatment that involves the use of photosensitizers to generate cytotoxic species, and kill cancer cells. The present work is focused on the synthesis and evaluation of the cytotoxicity of water-soluble pure and Ni-doped ZnSe@ZnS QDs in human-pancreatic carcinoma cells (PANC-1). QDs were fully characterized on a structural, morphological and optical viewpoint. The viability of PANC-1 decreased from 85.6±12.1% to 46.7±0.9% when contacted with 0 ppm and 300 ppm of pure QDs, respectively. The cytotoxicity of QDs was enhanced under UV-irradiation as a function of the exposure time. The viability of PANC-1 in presence of 50ppm of pure QDs decreased from 97.6 ± 4.1% (0-minutes of irradiation) down to 35.9 ± 4.4% (60-minutes of irradiation). Our results evidenced the feasibility of using selected QDs as a platform to generate cytotoxic species.