|About this Abstract
||Materials Science & Technology 2011
||MS&T'11 Poster Session
||030 Tricalcium Phosphate System in Drug Delivery and Bone Graft
||Joe Edgington, Susmita Bose, Amit Bandyopadhyay
|On-Site Speaker (Planned)
Recently, the lithium-doped tricalcium phosphate (Li-TCP) system has shown significant interests due to its performance toward enhanced osteoblast proliferative activity, and differentiation. The influence of Li-doping on mechanical and biological properties of TCP was investigated. Immunohistochemistry results indicated that the levels of Li-doping in β-TCP increase the level of differentiation in cells, as compared to undoped β-TCP. TCP coupled with polymer, e.g. polycaprolactone (PCL), proves to be an efficient system in protein or drug delivery. We are investigating the loading and release of agents such as bovine serum albumin (BSA), aspartic acid (ASP) and bone morphogenetic protein-2 (BMP-2) from a TCP delivery vehicle. The hypothesis is that protein or drug can be released in a controlled manner from the optimal TCP-polymer composite system. The poster will present both doped TCP and their composite system in drug delivery and bone tissue engineering.