Regulations in the automotive industry to reduce the CO2 emissions lead to an increased use of new materials and material combinations. The approach of hybrid materials and innovative multi-material design shows high potential in lightweight strategies as the best characteristics of each material is used at the right place. Multi-material design, e.g. thermoforming of aluminum and glassfibre-reinforced thermoplastic, allows decreasing car body weight at reasonable costs but also leads to new challenges in material and process modelling. As friction plays an important role during forming processes in which two surfaces are in contact, it must be correctly reproduced from the experimental results and transferred to the virtual simulation. In this paper, a methodology is presented to describe the process from experimental data acquisition to friction models which are applicable in the forming simulation. In a full factorial design of experiment, temperature, sliding velocity and pressure are varied using a pull-out testing device. In addition, two different material combinations are considered, namely aluminum – GFRP interaction and interply interaction between different layers of GFRP. The systematic evaluation shows the significance of these three parameters, their interactions and their influence on the friction coefficient. These results are incorporated in a friction model that is dependent on temperature, sliding velocity and pressure and is applied in LS-DYNA and PAM-FORM.