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Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Bio-nano Interfaces and Engineering Applications Symposium
Presentation Title New Antimicrobial Peptides Generated through Genetic Algorithm Approach Using Chemical Property Based Cross-over
Author(s) Kyle Boone, Kyle Camarda, Paulette Spencer, Candan Tamerler
On-Site Speaker (Planned) Kyle Boone
Abstract Scope Antibiotic-resistant bacteria cause many fatalities annually. Antimicrobial peptides have co-evolved with bacteria as natural antibiotics. We previously demonstrated that antimicrobial peptides when combined with an implant binding peptide can create a biomimetic interface and coat the implant surfaces. Motivated by these results, we also developed successful searches for new antimicrobial peptides using a genetic algorithm (GA) method. To target specific bacteria as well as broaden their effect, here we explore developing new sequences using computer-aided molecular design (CAMD) principles to translate the desired properties into novel antimicrobial peptide sequences. We advance our GA method by developing a novel sequence generation mechanism. We introduce the chemical property based cross over concept by grouping sequences before sequence generatation. The convergence rate of the average distance between property values and targets across generations will be compared between using inter-group crosses, intra-group crosses and both types of crosses to generate new sequences. 
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)


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Biomolecular Design of Soft Interfaces for Technology and Medicine
Chemically Functionalised Graphene FET with Double Conductance Minima for the Label-free Sensing of Exosomes
Connecting Biology and Electronics with Protons: From Ion Channels to Cells
Discovery of Biomaterials by Simulation and Experiment: Catalysts, Composites, and Therapeutics
Effects of Hydration and Mineralization on the Mechanical Behavior of Collagen Fibrils
Investigating the Interaction of Amyloidogenic Proteins with Inorganic Surfaces, Nanoparticles and Biomolecules by Atomistic Simulations
Modeling the Mechanics of Cancer Cells on Tissue Engineering Substrates
Nanoclay Based Tissue Engineering Scaffolds for Mimicking Biointerfaces in Mesenchymal to Epithelial Transision of Prostate and Breast Cancer Metastasis to Bone
Nanoscale Structure and Properties of Biomaterials
New Antimicrobial Peptides Generated through Genetic Algorithm Approach Using Chemical Property Based Cross-over
Oligopeptides and Recombinamers at Surfaces and Interfaces to Address Oral Infections
Revealing the Full Hierarchical Structure of Spider Silks across All Length Scales
Revealing the Multi-functional Surface and Material Property of Venus Flytrap (Dionaea Muscipula)
Single Molecular Imaging of Fluorescent-tagged Peptides Diffusing on a Surface of Boron Nitride
Surface Modification of Ti6Al4V to Confer Antibacterial Properties against Listeria Monocytogenes
Synthesis and Characterization of Superomniphobic Surfaces Inspired by Springtails
Transmission Synchrotron X-ray Tomography and Nano-indentation Measurements for the Investigation of the Teeth Microstructure of Dinosaurs
Use of Nanostructured Diamond in Medical Device Applications

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