During the last decade there have been significant advancements made in additive manufacturing technology that caused widespread change in the metal casting industry. Although the equipment and materials used are rapidly advancing, there is limited information regarding the process changes that influence the product created by this technology. Here, an investigation was conducted to realize the influence of machine settings on the physical characteristics of 3D printed sand. Two factorial matrices were constructed to directly measure the significance of six settings that change the resin content and compaction characteristics of the bonded sand. Factors include: X-resolution, printhead voltage, layer thickness, and the frequency, speed, and angle of the recoater blade. Responses include: density, permeability, strength, scratch hardness, loss-on-ignition, and print resolution. Several relationships are reported between machine settings and physical properties of the product. These results will help inform mold manufacturing as the foundry industry continues to adopt additive technologies.